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Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine-tuning
- Source :
- Development (Cambridge, England), Development (Cambridge, England), Company of Biologists, 2019, ⟨10.1242/dev.181024⟩
- Publication Year :
- 2019
- Publisher :
- The Company of Biologists Ltd, 2019.
-
Abstract
- How developing vascular networks acquire the right balance of arteries, veins and lymphatic vessels to efficiently supply and drain tissues is poorly understood. In zebrafish embryos, the robust and regular 50:50 global balance of intersegmental veins and arteries that form along the trunk prompts the intriguing question of how does the organism keep ‘count’? Previous studies have suggested that the ultimate fate of an intersegmental vessel (ISV) is determined by the identity of the approaching secondary sprout emerging from the posterior cardinal vein. Here, we show that the formation of a balanced trunk vasculature involves an early heterogeneity in endothelial cell behaviour and Notch signalling activity in the seemingly identical primary ISVs that is independent of secondary sprouting and flow. We show that Notch signalling mediates the local patterning of ISVs, and an adaptive flow-mediated mechanism subsequently fine-tunes the global balance of arteries and veins along the trunk. We propose that this dual mechanism provides the adaptability required to establish a balanced network of arteries, veins and lymphatic vessels.<br />Highlighted Article: A stepwise dual mechanism involving Notch signalling and flow provides the adaptability required to establish a balanced network of arteries and veins in the zebrafish trunk.
- Subjects :
- Vein
ANGIOGENESIS
0302 clinical medicine
NETWORK
Zebrafish
[SDV.BDD]Life Sciences [q-bio]/Development Biology
GENE-EXPRESSION
0303 health sciences
VENOUS DIFFERENTIATION
Receptors, Notch
Cell Polarity
Anatomy
Arteries
GRIDLOCK
Artery
Haemodynamic
Endothelial stem cell
medicine.anatomical_structure
Lymphatic system
cardiovascular system
Developmental patterning
Life Sciences & Biomedicine
Research Article
Signal Transduction
Notch
Notch signaling pathway
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
DLL4
Veins
03 medical and health sciences
Genetic Heterogeneity
medicine
Posterior cardinal vein
Animals
Molecular Biology
030304 developmental biology
Body Patterning
Lymphatic Vessels
Science & Technology
COMPLEX
Endothelial Cells
biology.organism_classification
Trunk
ENDOTHELIAL-CELLS
Cardiovascular and Metabolic Diseases
Regional Blood Flow
Angiogenesis
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 14779129 and 09501991
- Volume :
- 146
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Development (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....47c7b990a05e46895e4af8b787535241