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Occupational cohort study of current and former workers exposed to chrysotile in mine and processing facilities in Asbest, the Russian Federation: Cohort profile of the Asbest Chrysotile Cohort study
- Source :
- PLoS ONE, Vol 15, Iss 7, p e0236475 (2020), PLoS ONE, PLoS One, 15(7), 1. Public Library of Science
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- A historical cohort study in workers occupationally exposed to chrysotile was set up in the town of Asbest, the Russian Federation, to study their cause-specific mortality, with a focus on cancer. Chrysotile has different chemical and physical properties compared with other asbestos fibres; therefore it is important to conduct studies specifically of chrysotile and in different geographical regions to improve the knowledge about its carcinogenicity. Setting was the town of Asbest, Sverdlovsk oblast, the Russian Federation. Participants were all current and former employees with at least one year of employment between 1/1/1975 and 31/12/2010 in the mine, enrichment factories, auto-transport and external rail transportation departments, the central laboratory, and the explosives unit of the company. Of the 35,837 cohort members, 12,729 (35.5%) had died (2,373 of them of cancer, including 10 of mesothelioma), 18,799 (52.5%) were known to be alive at the end of the observation period (2015), and 4,309 (12.0%) were censored before the end of 2015. Mean follow-up duration was 21.7 years in men and 25.9 years in women. The mean age at death was 59.4 years in men and 66.5 years in women. This is the largest occupational cohort of chrysotile workers to date, and the only one with a large proportion of exposed female workers.
- Subjects :
- Male
Mesothelioma
Lung Neoplasms
Economics
Social Sciences
medicine.disease_cause
Biochemistry
Lung and Intrathoracic Tumors
Russia
Cohort Studies
Geographical Locations
Occupational Cohort
0302 clinical medicine
Chrysotile
Medicine and Health Sciences
Public and Occupational Health
030212 general & internal medicine
Materials
Multidisciplinary
Agricultural and Biological Sciences(all)
Dust
Middle Aged
030210 environmental & occupational health
Occupational Diseases
Europe
Oncology
Research Design
Physical Sciences
Cohort
Medicine
Female
Historical Cohort
Research Article
Cohort study
Adult
Employment
Asia
Asbestos, Serpentine
Science
Materials Science
Research and Analysis Methods
Asbestos
Rectal Cancer
03 medical and health sciences
Occupational Exposure
Environmental health
Gastrointestinal Tumors
medicine
Humans
General
Biochemistry, Genetics and Molecular Biology(all)
business.industry
Mesothelioma, Malignant
Cancers and Neoplasms
Gastric Cancer
Labor Economics
Rail transportation
People and Places
Russian federation
business
Genetics and Molecular Biology(all)
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....47c6bf1fe085bd01ac8bf72c25b1588a