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Anorectal Function with High-Resolution Anorectal Manometry in Active Ulcerative Colitis and after Remission: A Pilot Study
- Source :
- Reviews on Recent Clinical Trials. 17:97-102
- Publication Year :
- 2022
- Publisher :
- Bentham Science Publishers Ltd., 2022.
-
Abstract
- Background: Ulcerative colitis may impair anorectal function, causing disabling symp-toms such as incontinence and/or increase in the stool frequency, urgency and tenesmus. Data on anorectal function in these patients evaluated by conventional anorectal manometry are conflicting. Objectives: The aim of this prospective study was to assess by means of high resolution anorectal manometry the anorectal function in patients with mild-to-moderate ulcerative colitis at presentation and after remission. Anorectal function of ulcerative colitis patients was compared to that observed in healthy volunteers. Methods: 20 patients with mild to moderate left-sided ulcerative colitis or proctitis and 20 healthy volunteers were prospectively enrolled. All ulcerative colitis patients underwent high resolution ano-rectal manometry before treatment and after clinical remission. Results: Ulcerative colitis patients showed similar values for anal sphincter function as healthy vol-unteers, whereas rectal threshold volume for the first sensation, desire to defecate, urgency to defecate and maximum discomfort were significantly lower than in healthy volunteers (p Conclusions: Ulcerative colitis patients show altered rectal function, with increased rectal sensitivity and lower compliance, compared to controls. This altered function is restored after successful treat-ment of the underlying inflammatory process. Finally high resolution anorectal manometry provides useful information on anorectal functionality and, in our opinion, should be preferred over conven-tional manometry.
- Subjects :
- Pharmacology
Proctiti
Ulcerative coliti
Manometry
Remission Induction
Rectum
Anal Canal
Pilot Projects
General Medicine
HRAM
High-resolution anorectal manometry
Inflammatory bowel disease
Prospective Studie
Case-Control Studies
Humans
Pilot Project
Colitis, Ulcerative
Prospective Studies
Case-Control Studie
Human
Subjects
Details
- ISSN :
- 15748871
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Reviews on Recent Clinical Trials
- Accession number :
- edsair.doi.dedup.....47c1d11abecf04c1f197ca0cdc3ad58d
- Full Text :
- https://doi.org/10.2174/1574887117666220513110705