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Anorectal Function with High-Resolution Anorectal Manometry in Active Ulcerative Colitis and after Remission: A Pilot Study

Authors :
Antonietta G. Gravina
Alessandro Federico
Angela Facchiano
Giuseppe Scidà
Raffaele Pellegrino
Giovanna Palladino
Carmelina Loguercio
Ludovico Docimo
Marco Romano
Salvatore Tolone
Gravina, Antonietta G
Federico, Alessandro
Facchiano, Angela
Scidà, Giuseppe
Pellegrino, Raffaele
Palladino, Giovanna
Loguercio, Carmelina
Docimo, Ludovico
Romano, Marco
Tolone, Salvatore
Source :
Reviews on Recent Clinical Trials. 17:97-102
Publication Year :
2022
Publisher :
Bentham Science Publishers Ltd., 2022.

Abstract

Background: Ulcerative colitis may impair anorectal function, causing disabling symp-toms such as incontinence and/or increase in the stool frequency, urgency and tenesmus. Data on anorectal function in these patients evaluated by conventional anorectal manometry are conflicting. Objectives: The aim of this prospective study was to assess by means of high resolution anorectal manometry the anorectal function in patients with mild-to-moderate ulcerative colitis at presentation and after remission. Anorectal function of ulcerative colitis patients was compared to that observed in healthy volunteers. Methods: 20 patients with mild to moderate left-sided ulcerative colitis or proctitis and 20 healthy volunteers were prospectively enrolled. All ulcerative colitis patients underwent high resolution ano-rectal manometry before treatment and after clinical remission. Results: Ulcerative colitis patients showed similar values for anal sphincter function as healthy vol-unteers, whereas rectal threshold volume for the first sensation, desire to defecate, urgency to defecate and maximum discomfort were significantly lower than in healthy volunteers (p Conclusions: Ulcerative colitis patients show altered rectal function, with increased rectal sensitivity and lower compliance, compared to controls. This altered function is restored after successful treat-ment of the underlying inflammatory process. Finally high resolution anorectal manometry provides useful information on anorectal functionality and, in our opinion, should be preferred over conven-tional manometry.

Details

ISSN :
15748871
Volume :
17
Database :
OpenAIRE
Journal :
Reviews on Recent Clinical Trials
Accession number :
edsair.doi.dedup.....47c1d11abecf04c1f197ca0cdc3ad58d
Full Text :
https://doi.org/10.2174/1574887117666220513110705