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Prenatal fever and autism risk
- Source :
- Molecular Psychiatry
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- Some studies suggest that prenatal infection increases risk of autism spectrum disorders (ASDs). This study was undertaken in a prospective cohort in Norway to examine whether we could find evidence to support an association of the prenatal occurrence of fever, a common manifestation of infection, with ASD risk. Prospective questionnaires provided maternal exposure data; case status was established from clinical assessments and registry linkages. In a large, prospectively ascertained cohort of pregnant mothers and their offspring, we examined infants born greater than or equal to 32 weeks for associations between fever exposure in each trimester and ASD risk using logistic regression. Maternal exposure to second-trimester fever was associated with increased ASD risk, adjusting for presence of fever in other trimesters and confounders (adjusted odds ratio (aOR), 1.40; 95% confidence interval, 1.09–1.79), with a similar, but nonsignificant, point estimate in the first trimester. Risk increased markedly with exposure to three or more fever episodes after 12 weeks' gestation (aOR, 3.12; 1.28–7.63). ASD risk appears to increase with maternal fever, particularly in the second trimester. Risk magnified dose dependently with exposure to multiple fevers after 12 weeks' gestation. Our findings support a role for gestational maternal infection and innate immune responses to infection in the pathogenesis of at least some cases of ASD. publishedVersion
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Pediatrics
Fever
Autism Spectrum Disorder
Genetic Linkage
Maternal Fever
Mothers
Gestational Age
Infections
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Pregnancy
Risk Factors
Surveys and Questionnaires
Odds Ratio
medicine
Humans
Prospective Studies
Registries
Autistic Disorder
Psychiatry
Prospective cohort study
Molecular Biology
Norway
business.industry
Infant, Newborn
Infant
Gestational age
Odds ratio
medicine.disease
Immunity, Innate
3. Good health
Psychiatry and Mental health
030104 developmental biology
Maternal Exposure
Pregnancy Trimester, Second
Prenatal Exposure Delayed Effects
Cohort
Gestation
Autism
Original Article
Female
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 13594184
- Database :
- OpenAIRE
- Journal :
- Molecular Psychiatry
- Accession number :
- edsair.doi.dedup.....47bff1e6ef6c01cf3b4c1ba018dddc68