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Pharmacokinetics of Ginsenoside Compound K From a Compound K Fermentation Product, CK‐30, and From Red Ginseng Extract in Healthy Korean Subjects
- Source :
- Clinical Pharmacology in Drug Development. 10:1358-1364
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Natural protopanaxadiol ginsenosides exhibit low absorption in the human intestine. However, ginsenoside compound K (CK) with 1 conjugated glucose molecule exhibits favorable absorption. The purpose of this study was to compare the pharmacokinetics of ginsenoside CK from a CK fermentation product, CK-30, and from a red ginseng extract. A randomized, open-label, 2-treatment, 2×2 crossover study was conducted. The volunteers were randomly divided into 2 groups. One group received CK-30, and the other group received 2.94 g of a red ginseng extract. After a 7-day washout period, the subjects received an alternative treatment for a single dose. The pharmacokinetic parameters, including the maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve from time 0 to time of last measurable concentration, were calculated. The median time to reach Cmax of ginsenoside CK after administration of CK-30 was 3.0 hours, whereas the corresponding value of the red ginseng extract was 10.0 hours. Compared with the red ginseng extract, CK-30 resulted in a higher systemic exposure to ginsenoside CK, with a 118.3-fold increase in Cmax and a 135.1-fold increase in area under the plasma concentration-time curve from time 0 to time of last measurable concentration. The systemic exposure to ginsenoside CK was significantly higher after administration of CK-30 than red ginseng extract.
- Subjects :
- Adult
Male
Ginsenosides
Cmax
Biological Availability
Panax
Pharmaceutical Science
Absorption (skin)
Pharmacology
030226 pharmacology & pharmacy
Extracellular Vesicles
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pharmacokinetics
Republic of Korea
Humans
Medicine
Pharmacology (medical)
Cross-Over Studies
Plant Extracts
business.industry
Microbiota
Crossover study
Ginsenoside compound K
Healthy Volunteers
Gastrointestinal Microbiome
chemistry
Ginsenoside
030220 oncology & carcinogenesis
Fermentation
Protopanaxadiol
Metagenomics
business
Subjects
Details
- ISSN :
- 21607648 and 2160763X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical Pharmacology in Drug Development
- Accession number :
- edsair.doi.dedup.....47bed247029f642c2b167613991c0df7