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ACE insertion/deletion polymorphism (rs1799752) modifies the renoprotective effect of renin-angiotensin system blockade in patients with IgA nephropathy
- Source :
- Journal of the Renin-Angiotensin-Aldosterone System, Vol 16 (2015)
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Introduction: Little is known about genetic predictors that modify the renoprotective effect of renin-angiotensin system (RAS) blockade in IgA nephropathy (IgAN). Materials and methods: The present multicenter retrospective observational study examined effect modification between RAS blockade and three RAS-related gene polymorphisms in 237 IgAN patients, including ACE I/D (rs1799752), AT1R A1166C (rs5186) and AGT T704C (rs699). Results: During 9.9 ± 4.2 years of observation, 63 patients progressed to a 50% increase in serum creatinine level. Only ACE I/D predicted the outcome ( ACE DD vs ID/II, hazard ratio 1.86 (95% confidence interval 1.03, 3.33)) and modified the renoprotective effect of RAS blockade ( p for interaction between ACE DD and RAS blockade = 0.087). RAS blockade suppressed progression in ACE DD patients but not in ID/II patients ( ACE ID/II with RAS blockade as a reference; ID/II without RAS blockade 1.45 (0.72, 2.92); DD without RAS blockade 3.06 (1.39, 6.73); DD with RAS blockade 1.51 (0.54, 4.19)), which was ascertained in a model with the outcome of slope of estimated glomerular filtration rate ( p = 0.045 for interaction). Conclusion: ACE I/D predicted the IgAN progression and the renoprotective effect of RAS blockade in IgAN patients whereas neither AT1R A1166C nor AGT T704C did.
- Subjects :
- Adult
Male
Medicine (General)
medicine.medical_specialty
Biopsy
Renal function
Blood Pressure
Kidney
Protective Agents
Polymorphism, Single Nucleotide
Nephropathy
Renin-Angiotensin System
chemistry.chemical_compound
R5-920
Endocrinology
INDEL Mutation
Internal medicine
Renin–angiotensin system
Internal Medicine
medicine
Humans
Creatinine
business.industry
Hazard ratio
Glomerulonephritis, IGA
medicine.disease
Blockade
Blood pressure
medicine.anatomical_structure
chemistry
Female
business
Subjects
Details
- ISSN :
- 17528976 and 14703203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of the Renin-Angiotensin-Aldosterone System
- Accession number :
- edsair.doi.dedup.....47bc6bdd823c7ab8b1a52f5676ba4230