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Cross-protection against mucosal simian immunodeficiency virus (SIVsm) challenge in human immunodeficiency virus type 2-vaccinated cynomolgus monkeys
- Source :
- Journal of General Virology. 82:1601-1612
- Publication Year :
- 2001
- Publisher :
- Microbiology Society, 2001.
-
Abstract
- In this study we compared the efficacy of live attenuated human immunodeficiency virus type 2 (HIV-2) vaccine alone versus boosting with live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 env, gag and pol). Six monkeys were first inoculated intravenously with live HIV-2SBL-6669 and 7 to 10 months later were challenged intrarectally with 10 MID50 of cell-free simian immunodeficiency virus (SIV) strain SIVsm. One monkey was completely protected against SIV infection and all five monkeys that became SIV-infected showed a lower virus replication and an initial lower virus load as compared with a parallel group of six control animals. In another experiment five monkeys were immunized either three times with ALVAC HIV-2 alone or twice with ALVAC HIV-2 and once with purified native HIV-2 gp125. The monkeys were then challenged with HIV-2 given intravenously and finally with pathogenic SIVsm given intrarectally. After challenge with SIVsm, three of five monkeys were completely protected against SIVsm infection whereas the remaining two macaques became SIV-infected but with limited virus replication. In conclusion, vaccination with an ALVAC HIV-2 vaccine followed by exposure to live HIV-2 could induce cross-protection against mucosal infection with SIVsm and seemed to be more efficient than immunization with a live HIV-2 vaccine only.
- Subjects :
- Male
viruses
animal diseases
Genetic Vectors
Simian Acquired Immunodeficiency Syndrome
HIV Infections
Canarypox virus
Cross Reactions
Biology
Vaccines, Attenuated
medicine.disease_cause
Genes, env
Avipoxvirus
law.invention
Administration, Rectal
law
Virology
medicine
Animals
AIDS Vaccines
Vaccines, Synthetic
Mucous Membrane
Vaccination
virus diseases
Viral Load
Simian immunodeficiency virus
Genes, gag
Genes, pol
Mucosal Infection
Disease Models, Animal
Macaca fascicularis
Immunization
Viral replication
HIV-2
Injections, Intravenous
Immunology
Recombinant DNA
RNA, Viral
Female
Simian Immunodeficiency Virus
Viral load
Subjects
Details
- ISSN :
- 14652099 and 00221317
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Journal of General Virology
- Accession number :
- edsair.doi.dedup.....47b3ac6e0acb679b47edb5075b79d08d