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Neuropsychiatry and White Matter Microstructure in Huntington’s Disease
- Source :
- Journal of Huntington's Disease
- Publication Year :
- 2015
- Publisher :
- IOS Press, 2015.
-
Abstract
- Background: Neuropsychiatric symptoms in Huntington’s disease (HD) are often evident prior to clinical diagnosis. Apathy is highly correlated with disease progression, while depression and irritability occur at different stages of the disease, both before and after clinical onset. Little is understood about the neural bases of these neuropsychiatric symptoms and to what extent those neural bases are analogous to neuropsychiatric disorders in the general population. Objective: We used Diffusion Tensor Imaging (DTI) to investigate structural connectivity between brain regions and any putative microstructural changes associated with depression, apathy and irritability in HD. Methods: DTI data were collected from 39 premanifest and 45 early-HD participants in the Track-HD study and analysed using whole-brain Tract-Based Spatial Statistics. We used regression analyses to identify white matter tracts whose structural integrity (as measured by fractional anisotropy, FA) was correlated with HADS-depression, PBA-apathy or PBA-irritability scores in gene-carriers and related to cumulative probability to onset (CPO). Results: For those with the highest CPO, we found significant correlations between depression scores and reduced FA in the splenium of the corpus callosum. In contrast, those with lowest CPO demonstrated significant correlations between irritability scores and widespread FA reductions. There was no significant relationship between apathy and FA throughout the whole brain. Conclusions: We demonstrate that white matter changes associated with both depression and irritability in HD occur at different stages of disease progression concomitant with their clinical presentation.
- Subjects :
- Adult
Male
Research Report
medicine.medical_specialty
Apathy
Population
Splenium
Audiology
Corpus callosum
Irritability
050105 experimental psychology
White matter
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Huntington's disease
Surveys and Questionnaires
Fractional anisotropy
medicine
Humans
irritability
0501 psychology and cognitive sciences
education
Psychiatry
Depressive Disorder
education.field_of_study
05 social sciences
Middle Aged
diffusion tensor imaging
medicine.disease
White Matter
Irritable Mood
Huntington Disease
medicine.anatomical_structure
Behavior Rating Scale
depression
Anisotropy
Regression Analysis
Female
Neurology (clinical)
medicine.symptom
Psychology
030217 neurology & neurosurgery
Huntington’s disease
Subjects
Details
- ISSN :
- 18796400 and 18796397
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Huntington's Disease
- Accession number :
- edsair.doi.dedup.....47a47ac9cb6052c5a197bd762e7f9651