Back to Search
Start Over
Postoperative expressive aphasia associated with intravenous midazolam administration: a 5-year retrospective case-control study
- Source :
- The Journal of International Medical Research, Journal of International Medical Research, Vol 48 (2020)
- Publication Year :
- 2020
-
Abstract
- Objectives This study aimed to investigate the epidemiology of intravenous midazolam-induced postoperative expressive aphasia (EA). Methods The incidence rate, risk ratio, and contributing factors to intravenous midazolam-induced postoperative EA were analyzed retrospectively in 6756 orthopedic patients. A telephone interview was conducted with patients with EA after surgery. Results Patients were allocated to either the midazolam group (n = 6178) or no-midazolam group (n = 578). Twelve patients developed EA in the midazolam group, with an incidence of 0.19%, and no patient developed EA in the no-midazolam group. The mean age of EA patients was 70 years, and 92% were women. Among them, 75% received general anesthesia, and the mean dose of midazolam was 1.8 mg. EA was reversed in nine of 12 (75%) patients within 4 minutes of flumazenil administration, and >60 minutes were required to reverse EA in the other three patients (25%). Conclusion Intravenous midazolam administration for preoperative sedation caused transient EA in 0.19% of patients, especially elderly women who received general anesthesia, and EA could be reversed by flumazenil.
- Subjects :
- Flumazenil
Male
medicine.medical_specialty
Medicine (General)
genetic structures
Midazolam
anesthesia
Biochemistry
elderly
03 medical and health sciences
0302 clinical medicine
R5-920
Double-Blind Method
030202 anesthesiology
Epidemiology
medicine
Humans
heterocyclic compounds
030212 general & internal medicine
expressive aphasia
Aged
Retrospective Studies
Aphasia, Broca
business.industry
Biochemistry (medical)
Case-control study
Cell Biology
General Medicine
medicine.disease
Expressive aphasia
preoperative sedation
Anesthesia
Relative risk
Case-Control Studies
Female
business
medicine.drug
Retrospective Clinical Research Report
Subjects
Details
- ISSN :
- 14732300
- Volume :
- 48
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The Journal of international medical research
- Accession number :
- edsair.doi.dedup.....47a26481550991cdcbf6bb6a33dc0b07