Back to Search Start Over

Postoperative expressive aphasia associated with intravenous midazolam administration: a 5-year retrospective case-control study

Authors :
Yoo Jung Park
Jihyun Chung
Saecheol Oh
Sujin Baek
Source :
The Journal of International Medical Research, Journal of International Medical Research, Vol 48 (2020)
Publication Year :
2020

Abstract

Objectives This study aimed to investigate the epidemiology of intravenous midazolam-induced postoperative expressive aphasia (EA). Methods The incidence rate, risk ratio, and contributing factors to intravenous midazolam-induced postoperative EA were analyzed retrospectively in 6756 orthopedic patients. A telephone interview was conducted with patients with EA after surgery. Results Patients were allocated to either the midazolam group (n = 6178) or no-midazolam group (n = 578). Twelve patients developed EA in the midazolam group, with an incidence of 0.19%, and no patient developed EA in the no-midazolam group. The mean age of EA patients was 70 years, and 92% were women. Among them, 75% received general anesthesia, and the mean dose of midazolam was 1.8 mg. EA was reversed in nine of 12 (75%) patients within 4 minutes of flumazenil administration, and >60 minutes were required to reverse EA in the other three patients (25%). Conclusion Intravenous midazolam administration for preoperative sedation caused transient EA in 0.19% of patients, especially elderly women who received general anesthesia, and EA could be reversed by flumazenil.

Details

ISSN :
14732300
Volume :
48
Issue :
8
Database :
OpenAIRE
Journal :
The Journal of international medical research
Accession number :
edsair.doi.dedup.....47a26481550991cdcbf6bb6a33dc0b07