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High incidence of maternal parvovirus B19 infection in a large unselected population-based pregnancy cohort in Norway
- Source :
- Journal of Clinical Virology. 94:57-62
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Around 40% of pregnant women in Norway are parvovirus B19 (B19 V) seronegative and thus at risk for B19 V infection. Studies on samples from women with symptomatic disease or known exposure have shown that nucleic acid amplification assays combined with serology increase the sensitivity and improves the diagnostic procedure. Objectives The aim was to investigate the seroprevalence of B19 V infection, the occurrence of new infections and vertical transmission in a population-based pregnancy cohort, with special emphasis on the diagnostic methods. Study design We randomly selected 1350 pregnant women from the Norwegian Mother and Child Cohort Study (MoBa), using an algorithm for the detection of B19 V infection, including both serology and PCR. Results Maternal infection was confirmed in 50 subjects (3.7% of 1349 women), of which 35(70%) were viremic. Of the initially seronegative 33(6.8%) seroconverted. The estimated average annual seroconversion rate was 15.5%, with the highest estimated annual seroconversion rate of 31.6%. The rates of yearly seroconversion followed the pattern found in reports from Norwegian microbiology laboratories. Among all women, 31 (2.3%) had an inconclusive serological profile and 17 (54.8%) had detectable virus. Of the 16 women with virus detectable at gestational week 17–18, seven were still seronegative with absent seroconversion in the second sample taken at birth. All together 10 children were vertically infected. Conclusions High incidence of viremic B19 V infections and high estimated annual seroconversion rates were found. Lack of seroconversion despite longstanding viremia emphasizes the importance of including PCR when testing for B19 V infection during pregnancy.
- Subjects :
- Adult
medicine.medical_specialty
Population
Antibodies, Viral
Serology
Parvoviridae Infections
03 medical and health sciences
0302 clinical medicine
Pregnancy
Seroepidemiologic Studies
Virology
Parvovirus B19, Human
medicine
Humans
Seroprevalence
030212 general & internal medicine
Seroconversion
education
education.field_of_study
030219 obstetrics & reproductive medicine
biology
Norway
Parvovirus
Obstetrics
business.industry
Incidence
biology.organism_classification
medicine.disease
Infectious Diseases
Immunoglobulin M
Immunoglobulin G
Immunology
Cohort
Female
business
Algorithms
Cohort study
Subjects
Details
- ISSN :
- 13866532
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Virology
- Accession number :
- edsair.doi.dedup.....47a26351184bcda43e36fc38a5970556