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Solventless Synthesis of N‑Protected Amino Acids in a Ball Mill
- Source :
- ACS Sustainable Chemistry & Engineering, ACS Sustainable Chemistry & Engineering, American Chemical Society, 2013, 1 (9), pp.1186-1191. ⟨10.1021/sc4001115⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; An eco-friendly methodology for preparing carbamate N-protected α-amino acids is described using ball-milling technology. Some β-amino acids were also investigated in this study. This solvent-free methodology gave Boc-, Z-, and Fmoc-N-protected compounds in good to excellent yields with improved environmental impact compared to classical syntheses in solution. Different planetary ball mills were employed. The results are also discussed according to the different process parameters (grinding material, number of balls, rotation speed).
- Subjects :
- Carbamate
Materials science
General Chemical Engineering
medicine.medical_treatment
Protective groups
E factor
010402 general chemistry
01 natural sciences
E-factor
Solvent free
Mechanochemistry
medicine
Environmental Chemistry
Organic chemistry
Ball mill
Amino Acids
chemistry.chemical_classification
010405 organic chemistry
Renewable Energy, Sustainability and the Environment
[CHIM.ORGA]Chemical Sciences/Organic chemistry
General Chemistry
0104 chemical sciences
Grinding
Amino acid
chemistry
Mechanosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 21680485
- Database :
- OpenAIRE
- Journal :
- ACS Sustainable Chemistry & Engineering, ACS Sustainable Chemistry & Engineering, American Chemical Society, 2013, 1 (9), pp.1186-1191. ⟨10.1021/sc4001115⟩
- Accession number :
- edsair.doi.dedup.....47968d76482b974b742da54281fda41d