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Diesel Exhaust Particles Enhance Airway Responsiveness Following Allergen Exposure in Mice
- Source :
- Immunopharmacology and Immunotoxicology. 20:329-336
- Publication Year :
- 1998
- Publisher :
- Informa UK Limited, 1998.
-
Abstract
- We have previously reported that intratracheal instillation of diesel exhaust particles (DEP) enhances allergen-induced eosinophilic airway inflammation, local expression of interleukin-5 and granulocyte macrophage-colony stimulating factor, and allergen-specific production of IgE and IgG in mice. The present study was undertaken to elucidate the effects of DEP on airway hyperresponsiveness as another characteristic feature of allergic asthma. The animals were randomized into four experimental groups that received intratracheal instillation with vehicle, ovalbumin (OVA), DEP, or the combination of OVA and DEP on a weekly basis for 6 weeks. Respiratory resistance (Rrs) was measured 24 h after the last instillation. An increase in Rrs in animals that inhaled acetylcholine was significantly greater in the combined treatment with OVA and DEP than in the other treatments. The present study indicates that DEP can enhance airway responsiveness associated with allergen exposure, and provides experimental evidence that DEP may deteriorate the pathophysiology of allergen-related respiratory disease such as allergic asthma.
- Subjects :
- Male
Allergy
Ovalbumin
Immunology
Granulocyte
Toxicology
medicine.disease_cause
Immunoglobulin E
complex mixtures
Mice
Random Allocation
Airway resistance
Allergen
medicine
Animals
Immunology and Allergy
Respiratory system
Vehicle Emissions
Asthma
Pharmacology
Mice, Inbred ICR
biology
business.industry
Airway Resistance
General Medicine
Allergens
respiratory system
medicine.disease
Acetylcholine
respiratory tract diseases
medicine.anatomical_structure
biology.protein
Bronchial Hyperreactivity
business
Subjects
Details
- ISSN :
- 15322513 and 08923973
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Immunopharmacology and Immunotoxicology
- Accession number :
- edsair.doi.dedup.....4789e6c7765446d94dddf200addba8fa