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Genes associated with Type 2 Diabetes and vascular complications
- Source :
- Aging (Albany NY)
- Publication Year :
- 2018
-
Abstract
- Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro- and macrovascular complications that increase the morbidity and mortality of patients. The risk of diabetic complications has a strong genetic component. To this end, we sought to evaluate the association of 40 single nucleotide polymorphisms (SNPs) in 21 candidate genes with T2D and its vascular complications in 503 T2D patients and 580 healthy controls. The genes were chosen because previously reported to be associated with T2D complications and/or with the aging process. We replicated the association of T2D risk with IGF2BP rs4402960 and detected novel associations with TERT rs2735940 and rs2736098. The addition of these SNPs to a model including traditional risk factors slightly improved risk prediction. After stratification of patients according to the presence/absence of vascular complications, we found significant associations of variants in the CAT, FTO, and UCP1 genes with diabetic retinopathy and nephropathy. Additionally, a variant in the ADIPOQ gene was found associated with macrovascular complications. Notably, these genes are involved in some way in mitochondrial biology and reactive oxygen species regulation. Hence, our findings strongly suggest a potential link between mitochondrial oxidative homeostasis and individual predisposition to diabetic vascular complications.
- Subjects :
- 0301 basic medicine
Male
Candidate gene
endocrine system diseases
SNP
030209 endocrinology & metabolism
Single-nucleotide polymorphism
diabetes complication
Type 2 diabetes
ADIPOQ Gene
Bioinformatics
Polymorphism, Single Nucleotide
Nephropathy
03 medical and health sciences
0302 clinical medicine
Medicine
Humans
Genetic Predisposition to Disease
Gene
Telomerase
Aged
Type 2 Diabete
business.industry
aging
diabetes complications
RNA-Binding Proteins
nutritional and metabolic diseases
Cell Biology
Diabetic retinopathy
Middle Aged
medicine.disease
Type 2 Diabetes
030104 developmental biology
Diabetes Mellitus, Type 2
Area Under Curve
Case-Control Studies
Female
business
Diabetic Angiopathies
genetic profile
Research Paper
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Aging (Albany NY)
- Accession number :
- edsair.doi.dedup.....4772d87edfd89d26e7007f3e72e5c90d