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Infective endocarditis in patients with heart transplantation
- Source :
- INTERNATIONAL JOURNAL OF CARDIOLOGY, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, International Journal of Cardiology, International Journal of Cardiology, 2021, 328, pp.158-162. ⟨10.1016/j.ijcard.2020.12.018⟩, Digital.CSIC. Repositorio Institucional del CSIC, International Journal of Cardiology, Elsevier, 2021, 328, pp.158-162. ⟨10.1016/j.ijcard.2020.12.018⟩, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Publication Year :
- 2021
- Publisher :
- ELSEVIER IRELAND LTD, 2021.
-
Abstract
- [Background] The incidence of nosocomial and health care-related infective endocarditis (IE) is increasing. Heart transplantation (HT) implies immunosuppression and frequent health care contact. Our aim was to describe the current profile and prognosis of IE in HT recipients.<br />[Methods] Multicenter retrospective registry-based study in Spain and France that included cases between 2008 and 2019.<br />[Results] During the study period, 8305 HT were performed in Spain and France. We identified 18 IE cases (rate 0.2%). Median age was 57 years; 12 were men (67%). Valve involvement did not have a predominant location and three patients (16.7%) had atrial or ventricular vegetations without valve involvement. The median age-adjusted Charlson index was 4 (interquartile range 3–5). Eleven IE cases (61%) were nosocomial/health care-related. Median time (range) between HT and development of IE was 43 months (interquartile range 6–104). The major pathogens were Staphylococcus sp. (n = 8, 44%), Enterococcus sp. (n = 4, 22%), and Aspergillus sp. (n = 3, 17%). Although eight patients (44%) had a surgical indication, it was only performed in three cases (17%). Three patients (17%) died during the first IE hospital admission.<br />[Conclusions] IE in HT recipients has specific characteristics. Valve involvement does not have a predominant location and non-valvular involvement is common. Three fifths have a nosocomial/health care-related origin. The major pathogens were staphylococci (44%), enterococci (22%), and Aspergillus (17%). In-hospital mortality was 17%.
- Subjects :
- Male
medicine.medical_specialty
Etiology
Infecciones bacterianas
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Enfermedad cardiovascular
Charlson index
030204 cardiovascular system & hematology
Heart transplantation
03 medical and health sciences
0302 clinical medicine
Interquartile range
Internal medicine
medicine
Humans
In patient
030212 general & internal medicine
Trasplante de corazón
Hospital Mortality
Etiology, Heart transplantation, Infective endocarditis, Prognosis
Retrospective Studies
Bacteria
Endocarditis
business.industry
Incidence (epidemiology)
Immunosuppression
Endocarditis, Bacterial
Middle Aged
medicine.disease
Prognosis
3. Good health
Trasplante de órganos
Spain
Infective endocarditis
Female
France
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 01675273 and 18741754
- Database :
- OpenAIRE
- Journal :
- INTERNATIONAL JOURNAL OF CARDIOLOGY, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, International Journal of Cardiology, International Journal of Cardiology, 2021, 328, pp.158-162. ⟨10.1016/j.ijcard.2020.12.018⟩, Digital.CSIC. Repositorio Institucional del CSIC, International Journal of Cardiology, Elsevier, 2021, 328, pp.158-162. ⟨10.1016/j.ijcard.2020.12.018⟩, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Accession number :
- edsair.doi.dedup.....476a0051ad552670336ba4fdfb820005