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Advances in Imaging Reactive Oxygen Species

Authors :
Joachim Justad Røise
I-Che Li
Riddha Das
Eli M. Espinoza
Niren Murthy
Source :
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 62, iss 4, J Nucl Med
Publication Year :
2020
Publisher :
Society of Nuclear Medicine, 2020.

Abstract

Reactive oxygen species (ROS) play a pivotal role in many cellular processes and can be either beneficial or harmful. The design of ROS-sensitive fluorophores has allowed for imaging of specific activity and has helped elucidate mechanisms of action for ROS. Understanding the oxidative role of ROS in the many roles it plays allows us to understand the human body. This review provides a concise overview of modern advances in the field of ROS imaging. Indeed, much has been learned about the role of ROS throughout the years; however, it has recently been shown that using nanoparticles, rather than individual small organic fluorophores, for ROS imaging can further our understanding of ROS.

Details

ISSN :
2159662X and 01615505
Volume :
62
Database :
OpenAIRE
Journal :
Journal of Nuclear Medicine
Accession number :
edsair.doi.dedup.....4765cad10381285e06f848f0b121dcdd
Full Text :
https://doi.org/10.2967/jnumed.120.245415