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Cerebellar compartments for the processing of kinematic and kinetic information related to hindlimb stepping
- Publication Year :
- 2017
-
Abstract
- We previously showed that proprioceptive sensory input from the hindlimbs to the anterior cerebellar cortex of the cat may not be simply organized with respect to a body map, but it may also be distributed to multiple discrete functional areas extending beyond classical body map boundaries. With passive hindlimb stepping movements, cerebellar activity was shown to relate to whole limb kinematics as does the activity of dorsal spinocerebellar tract (DSCT) neurons. For DSCT activity, whole limb kinematics provides a solid functional framework within which information about limb forces, such as those generated during active stepping, may also be embedded. In this study, we investigated this idea for the spinocerebellar cortex activity by examining the activity of cerebellar cortical neurons during both passive bipedal hindlimb stepping and active stepping on a treadmill. Our results showed a functional compartmentalization of cerebellar responses to hindlimb stepping movements depending on the two types of stepping and strong relationships between neural activities and limb axis kinematics during both. In fact, responses to passive and active stepping were generally different, but in both cases their waveforms were related strongly to the limb axis kinematics. That is, the different stepping conditions modified the kinematics representation without producing different components in the response waveforms. In sum, cerebellar activity was consistent with a global kinematics framework serving as a basis upon which detailed information about limb mechanics and/or about individual limb segments might be imposed.
- Subjects :
- 0301 basic medicine
Patch-Clamp Techniques
Kinematics
Computer science
Hindlimb
Sensorimotor integration
Settore BIO/09
03 medical and health sciences
Cerebellar Cortex
Purkinje Cells
0302 clinical medicine
Gait (human)
Sensory mapping
Cortex (anatomy)
medicine
Animals
Gait
Neurons
Spinocerebellar tract
Neuroscience (all)
Proprioception
General Neuroscience
Dorsal spinocerebellar tract
Locomotion
Electroencephalography
Biomechanical Phenomena
030104 developmental biology
medicine.anatomical_structure
Cerebellar cortex
Spinocerebellar Tracts
Cats
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4755b58bf0edf5fcfa6000a1ae1ff5dd