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Testosterone ameliorates vascular aging via the Gas6/Axl signaling pathway
- Source :
- Aging (Albany NY)
- Publication Year :
- 2020
- Publisher :
- Impact Journals, LLC, 2020.
-
Abstract
- Low serum testosterone level is associated with aging-related vascular stiffness, but the underlying mechanism is unclear. The Growth arrest-specific protein 6 (Gas6) /Axl pathway has been proved to play important roles in cell senescence. In this study, we intend to explore whether Gas6/Axl is involved in the effect of testosterone on vascular aging amelioration. Vascular aging models of wild type and Axl-/- mice were established by natural aging. Mice of these two gene types were randomized into young group, aging group and testosterone undecanoate (TU) treatment group. Mice were treated with TU (37.9 mg/kg) in the TU group, which treated with solvent reagent served as control. The aging mice exhibited decreases in serum testosterone, Gas6 and Axl levels and an increase in cell senescence, manifested age-related vascular remodeling. Testosterone treatment induced testosterone and Gas6 levels in serum, and ameliorated cell senescence and vascular remodeling in aging mice. Furthermore, we uncover the underlying molecular mechanism and show that testosterone treatment restored the phosphorylation of Akt and FoxO1a. Axl knockout accelerated cell senescence and vascular remodeling, and resisted the anti-aging effect of testosterone. Testosterone might exert a protective effect on vascular aging by improving cell senescence and vascular remodeling through the Gas6/Axl pathway.
- Subjects :
- Male
Senescence
Aging
medicine.medical_specialty
Cell
Vascular Remodeling
Vascular Stiffness
Proto-Oncogene Proteins
Gas6
Internal medicine
medicine
Animals
Arterial Pressure
Testosterone
Phosphorylation
Protein kinase B
Aorta
Cellular Senescence
Mice, Knockout
Forkhead Box Protein O1
GAS6
business.industry
Age Factors
Wild type
Receptor Protein-Tyrosine Kinases
Axl
Cell Biology
Fibrosis
Axl Receptor Tyrosine Kinase
Carotid Arteries
medicine.anatomical_structure
Endocrinology
vascular aging
Intercellular Signaling Peptides and Proteins
vascular stiffening
Signal transduction
business
Proto-Oncogene Proteins c-akt
Signal Transduction
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....474390968d195aa70efad56f61c78a0c