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CT imaging and histopathological features of renal epithelioid angiomyolipomas

Authors :
X.-M. Fang
Alexander Lerner
J.-G. Zhang
X.-y. Hu
Z.-M. Zhu
L. Cui
X.-J. Yao
Source :
Clinical radiology. 67(12)
Publication Year :
2012

Abstract

Aim To describe computed tomography (CT) imaging and histopathological manifestations of renal epithelioid angiomyolipomas (EAMLs) for better understanding and cognition in the diagnosis of this new category of renal tumours. Materials and methods Clinical data and CT images from 10 cases of EAML were retrospectively analysed. All patients underwent CT with and without contrast medium administration, with multiplanar reconstruction (MPR) when needed. Results Plain CT manifestations of EAMLs were a higher density of mass (10–25 HU) than renal parenchyma, bulging contour of the involved kidney, absence of fat, distinct edges without a lobulate appearance. Contrast-enhanced CT features were markedly heterogeneous enhancement (from rapid wash-in to slow wash-out), large tumour size without lobular appearance, complete capsule with distinct margins and frequent mild necrotic areas. Histopathological features were epithelioid cells with eosinophilic cytoplasm, large and deeply stained nuclei, and dense arrangement of tumour cells with patchy necrosis; diffuse sheets of epithelioid cells were positive for HMB-45 (melanoma-associated antigen) and negative for epithelial membrane antigen (EMA) staining. Conclusion Multiple specific CT features correlated well with the histopathology and may play an important role in the primary diagnosis of EAMLs.

Details

ISSN :
1365229X
Volume :
67
Issue :
12
Database :
OpenAIRE
Journal :
Clinical radiology
Accession number :
edsair.doi.dedup.....4740ece0d7af3b87bc12bc59319b9c9a