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Factors predicting the therapeutic outcome of duodenal ulcer treatment with H2-receptor antagonists
- Source :
- Klinische Wochenschrift. 63:1152-1159
- Publication Year :
- 1985
- Publisher :
- Springer Science and Business Media LLC, 1985.
-
Abstract
- In a prospective trial 37 duodenal ulcer patients were treated daily with 1 g cimetidine. Personal and clinical data were obtained for all patients, acid secretion studies performed before and during treatment, and pharmacokinetic parameters of cimetidine determined. The healing rate after 4 weeks was 64.9% (24 patients). Non-Responders included a higher proportion of smokers, patients with a history of ulcer and previous treatment with H2-receptor antagonists than Responders. Basal acid output (BAO) and peak acid output (PAO) values were not different between the two groups, nor was the reduction of BAO and PAO under cimetidine. However, more Responders had complete suppression of BAO than Non-Responders. A correlation existed in both groups between cimetidine plasma concentration and PAO suppression but not with BAO suppression. Regular drug intake (compliance) was found in about 90% in both groups. Cimetidine bioavailability parameters were identical in both groups, but Non-Responders had a higher peak concentration and a shorter time of peak concentration. Discriminant analysis enabled a prediction of treatment response in 89.2% of the patients by using five factors: time of peak concentration of cimetidine, previous H2-receptor-antagonist treatment, peak concentration, smoking, and alcohol use. Prediction of treatment response is increased by use of drug related variables.
- Subjects :
- Adult
Male
Drug
medicine.medical_specialty
media_common.quotation_subject
Gastroenterology
Gastric Acid
Basal (phylogenetics)
Histamine H2 receptor
Pharmacokinetics
Internal medicine
Drug Discovery
medicine
Humans
Cimetidine
Duodenoscopy
Genetics (clinical)
media_common
Wound Healing
business.industry
General Medicine
Prognosis
Bioavailability
Duodenal ulcer
Kinetics
Endocrinology
Duodenal Ulcer
Molecular Medicine
Gastric acid
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14321440 and 00232173
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Klinische Wochenschrift
- Accession number :
- edsair.doi.dedup.....473b768172842841fa0cbe77ca8ed9f2