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Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19
- Source :
- PLoS ONE, Vol 17, Iss 1, p e0260897 (2022), PLoS ONE, PLOS ONE, 17(1):e0260897. Public Library of Science
- Publication Year :
- 2022
- Publisher :
- Public Library of Science (PLoS), 2022.
-
Abstract
- Background Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest with varying disease severity and mortality. Genetic predisposition influences the clinical course of infectious diseases. We investigated whether genetic polymorphisms in candidate genes ACE2, TIRAP, and factor X are associated with clinical outcomes in COVID-19. Methods We conducted a single-centre retrospective cohort study. All patients who visited the emergency department with SARS-CoV-2 infection proven by polymerase chain reaction were included. Single nucleotide polymorphisms in ACE2 (rs2285666), TIRAP (rs8177374) and factor X (rs3211783) were assessed. The outcomes were mortality, respiratory failure and venous thromboembolism. Respiratory failure was defined as the necessity of >5 litres/minute oxygen, high flow nasal oxygen suppletion or mechanical ventilation. Results Between March and April 2020, 116 patients (35% female, median age 65 [inter quartile range 55–75] years) were included and treated according to the then applicable guidelines. Sixteen patients (14%) died, 44 patients (38%) had respiratory failure of whom 23 required endotracheal intubation for mechanical ventilation, and 20 patients (17%) developed venous thromboembolism. The percentage of TIRAP polymorphism carriers in the survivor group was 28% as compared to 0% in the non-survivor group (p = 0.01, Bonferroni corrected p = 0.02). Genotype distribution of ACE2 and factor X did not differ between survivors and non-survivors. Conclusion This study shows that carriage of TIRAP polymorphism rs8177374 could be associated with a significantly lower mortality in COVID-19. This TIRAP polymorphism may be an important predictor in the outcome of COVID-19.
- Subjects :
- RNA viruses
Male
Viral Diseases
Critical Care and Emergency Medicine
Pulmonology
Coronaviruses
Physiology
Single Nucleotide Polymorphisms
Immune Receptors
Biochemistry
Severity of Illness Index
Cohort Studies
Medical Conditions
Immune Physiology
Receptors
Medicine and Health Sciences
Toll-like Receptors
Pathology and laboratory medicine
COVID-19/epidemiology
Netherlands
Receptors, Interleukin-1/genetics
Innate Immune System
Immune System Proteins
Membrane Glycoproteins
Multidisciplinary
Genetic Predisposition to Disease/genetics
Medical microbiology
Middle Aged
Polymorphism, Single Nucleotide/genetics
Angiotensin-Converting Enzyme 2/genetics
Infectious Diseases
Treatment Outcome
Viruses
Cytokines
Medicine
Female
Angiotensin-Converting Enzyme 2
SARS CoV 2
Pathogens
Single Nucleotide/genetics
Research Article
Signal Transduction
Factor X/genetics
SARS coronavirus
Genotype
Science
Immunology
Netherlands/epidemiology
Microbiology
Polymorphism, Single Nucleotide
Respiratory Disorders
Respiratory Failure
SARS-CoV-2/genetics
Genetics
Humans
Genetic Predisposition to Disease
Polymorphism
Aged
Retrospective Studies
Biology and life sciences
SARS-CoV-2
Organisms
Viral pathogens
Proteins
COVID-19
Receptors, Interleukin-1
Covid 19
Cell Biology
Membrane Glycoproteins/genetics
Interleukin-1/genetics
Molecular Development
Microbial pathogens
Immune System
Respiratory Infections
Factor X
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....472dd622c6c7fa7427174396a018c8aa