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The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films
- Source :
- Biomaterials
- Publication Year :
- 2009
-
Abstract
- Poly(lactide-co-glycolide) (PLGA) has been widely used for bone tissue regeneration. However, it lacks hydrophilicity, bioactivity and sufficient mechanical strength and its acidic degradation by-products can lead to pH decrease in the vicinity of the implants. Mesoporous bioactive glass (MBG) with highly ordered structure (pore size 2-50nm) possesses higher bioactivity than non-mesoporous bioactive glass (BG). The aim of this study is to investigate the effect of MBG on the mechanical strength, in vitro degradation, bioactivity, cellular response and drug release of PLGA films and optimize their physicochemical, biological and drug-delivery properties for bone tissue engineering application. The surface and inner microstructure, mechanical strength and surface hydrophilicity of MBG/PLGA and BG/PLGA films were tested. Results indicated that MBG or BG was uniformly dispersed in the PLGA films. The incorporation of MBG into PLGA films significantly improved their tensile strength, modulus and surface hydrophilicity. MBG/PLGA resulted in an enhanced mechanical strength, in vitro degradation (water absorbance, weight loss and ions release), apatite-formation ability and pH stability in simulated body fluids (SBF), compared to BG/PLGA. MBG/PLGA and BG/PLGA films enhanced human osteoblastic-like cells (HOBs) attachment, spreading and proliferation compared to PLGA. HOBs differentiation was significantly upregulated when cells were cultured on 30 MBG/PLGA for 14 days, compared to 30 BG/PLGA. MBG/PLGA enhanced the accumulative release of dexamethazone (DEX) at early stages (0-200h) compared to BG/PLGA, however, after 200h, DEX-release rates for MBG/PLGA was slower than that of BG/PLGA. The contents of MBG in PLGA films can control the amount of DEX released. Taken together, MBG/PLGA films possessed excellent physicochemical, biological and drug-release properties, indicating their potential application for bone tissue engineering by designing 3D scaffolds according to their corresponding compositions.
- Subjects :
- Materials science
Chemical Phenomena
Biophysics
Bioengineering
macromolecular substances
Bone tissue
law.invention
091200 MATERIALS ENGINEERING
Biomaterials
chemistry.chemical_compound
Polylactic Acid-Polyglycolic Acid Copolymer
law
Ultimate tensile strength
medicine
Mesoporous bioactive glass
PLGA
Osteoblasts
Dexamethazone
Drug release
Humans
Lactic Acid
Composite material
Biology
technology, industry, and agriculture
Microstructure
090300 BIOMEDICAL ENGINEERING
090400 CHEMICAL ENGINEERING
medicine.anatomical_structure
Chemical engineering
chemistry
Pharmaceutical Preparations
Mechanics of Materials
Bioactive glass
Ceramics and Composites
Glass
Poly dl lactide co glycolide
Mesoporous material
Porosity
Polyglycolic Acid
Subjects
Details
- ISSN :
- 18785905
- Volume :
- 30
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....472a44f7bc2b1408c2f4755ff3cb42a3