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A Rare Case of Lupus Nephritis Presenting as Thrombotic Microangiopathy with Diffuse Pseudotubulization Possibly Caused by Atypical Hemolytic Uremic Syndrome
- Source :
- Internal Medicine
- Publication Year :
- 2018
- Publisher :
- Japanese Society of Internal Medicine, 2018.
-
Abstract
- A 31-year-old woman was admitted to our hospital for thrombotic microangiopathy (TMA). She was diagnosed with systemic lupus erythematosus (SLE) and class V lupus nephritis. She had no aggravated SLE activity, Shiga toxin positivity, ADAMTS13 abnormality, or other causes of secondary TMA. Plasma exchange partially improved TMA, and eculizumab was introduced for suspected atypical hemolytic uremic syndrome (aHUS), as eculizumab was effective in suppressing the TMA activity. A kidney biopsy revealed diffusely organized crescents (pseudotubulization) with glomerular and arteriolar endothelial injury and subepithelial immune deposits. Thus, this was a rare case of lupus nephritis presenting as TMA with pseudotubulization possibly caused by aHUS.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Thrombotic microangiopathy
medicine.medical_treatment
Lupus nephritis
Case Report
030204 cardiovascular system & hematology
Antibodies, Monoclonal, Humanized
urologic and male genital diseases
03 medical and health sciences
0302 clinical medicine
systemic lupus erythematosus
immune system diseases
hemic and lymphatic diseases
Atypical hemolytic uremic syndrome
Biopsy
Internal Medicine
medicine
Humans
Lupus Erythematosus, Systemic
030212 general & internal medicine
skin and connective tissue diseases
Kidney
Plasma Exchange
medicine.diagnostic_test
Thrombotic Microangiopathies
atypical hemolytic uremic syndrome
business.industry
pseudotubulization
Plasmapheresis
General Medicine
Eculizumab
medicine.disease
Lupus Nephritis
female genital diseases and pregnancy complications
ADAMTS13
thrombotic microangiopathy
medicine.anatomical_structure
Female
eculizumab
business
medicine.drug
Subjects
Details
- ISSN :
- 13497235 and 09182918
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi.dedup.....471f86793fe4c61fbefb70f67d3b2136