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Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity
- Source :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 128(5)
- Publication Year :
- 2016
-
Abstract
- Objective We describe temporal spread imaging (TSI) that can identify the spatiotemporal pattern of epileptic activity using Magnetoencephalography (MEG). Methods A three-dimensional grid of voxels covering the brain is created. The array-gain minimum-variance spatial filter is applied to an interictal spike to estimate the magnitude of the source and the time (Ta) when the magnitude exceeds a predefined threshold at each voxel. This calculation is performed through all spikes. Each voxel has the mean Ta ( ) and spike number (N sp ), which is the number of spikes whose source exceeds the threshold. Then, a random resampling method is used to determine the cutoff value of N sp for the statistically reproducible pattern of the activity. Finally, all the voxels where the source exceeds the threshold reproducibly shown on the MRI with a color scale representing . Results Four patients with intractable mesial temporal lobe epilepsy (MTLE) were analyzed. In three patients, the common pattern of the overlap between the propagation and the hypometabolism shown by fluorodeoxyglucose-positron emission tomography (FDG-PET) was identified. Conclusions TSI can visualize statistically reproducible patterns of the temporal and spatial spread of epileptic activity. Significance TSI can assess the statistical significance of the spatiotemporal pattern based on its reproducibility.
- Subjects :
- 0301 basic medicine
Adult
Male
computer.software_genre
03 medical and health sciences
0302 clinical medicine
Voxel
Fluorodeoxyglucose F18
Physiology (medical)
medicine
Cutoff
Humans
Ictal
Physics
medicine.diagnostic_test
Spatial filter
business.industry
Spatiotemporal pattern
Magnetoencephalography
Reproducibility of Results
Pattern recognition
Magnetic Resonance Imaging
Sensory Systems
030104 developmental biology
Neurology
Epilepsy, Temporal Lobe
Positron emission tomography
Positron-Emission Tomography
Female
Neurology (clinical)
Artificial intelligence
Tomography
Radiopharmaceuticals
business
Nuclear medicine
computer
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18728952
- Volume :
- 128
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....471f749886b5d0841e99adf6a406b190