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Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood
- Source :
- Leukemialymphoma. 61(9)
- Publication Year :
- 2020
-
Abstract
- Although considered the same disease by 2016 WHO Classification, B-ALL and B-LBL show different clinicobiologic behavior, with B-ALL manifesting as disseminated disease and B-LBL as a localized mass. Distinction between the two is based on an arbitrary cutoff of 25% bone marrow involvement. We reviewed clinical, immunophenotypic, and cytogenetic data in B-lymphoblastic neoplasms of childhood to explain the differences. Performing a retrospective review of 126 cases of B-ALL and 18 cases of B-LBL in patients ≤18 years, revealed the following significant differences: younger age of presentation for leukemia; increased cytogenetic abnormalities in leukemia than lymphoma, specifically increased recurrent genetic abnormalities, with the exception of ploidy aberrancy; and the observation that unfavorable recurrent genetic abnormalities occurred in B-ALL and only favorable abnormalities in B-LBL. Down syndrome presented with leukemia only. Findings demonstrated that pediatric B-ALL and B-LBL exhibit dissimilar genomic profiles, suggesting possible differences in pathogenesis between the two closely-related neoplasms.
- Subjects :
- Cancer Research
Down syndrome
Pathology
medicine.medical_specialty
Lymphoma, B-Cell
03 medical and health sciences
0302 clinical medicine
medicine
Leukemia, B-Cell
Humans
Disseminated disease
Child
Retrospective Studies
B Lymphoblastic Lymphoma
Acute leukemia
business.industry
Lymphoblastic lymphoma
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Lymphoma
Leukemia
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Cytogenetic Analysis
Bone marrow
business
030215 immunology
Subjects
Details
- ISSN :
- 10292403
- Volume :
- 61
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Leukemialymphoma
- Accession number :
- edsair.doi.dedup.....47180954d4ef3c62aee9879b010cbc20