Back to Search
Start Over
Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus
- Source :
- Nature. 287(5780)
- Publication Year :
- 1980
-
Abstract
- Double-stranded DNA copies of the RNA gene coding for the haemagglutinin glycoproteins from human H2 and H3 pandemic strains of influenza virus have been cloned. DNA sequence analysis provides the first reported complete nucleotide sequence of an H2 haemagglutinin gene and a partial sequence (45%) of the H3 gene. The H2 haemagglutinin gene consists of 1,773 nucleotides containing an uninterrupted coding sequence of 1,686 nucleotides specifying a protein of 562 amino acids. Comparison of the amino acid sequences of these haemagglutinins with those of other H3 and avian strains reveals the extent of sequence changes in antigenic shifts and drifts.
- Subjects :
- animal structures
Genes, Viral
Sequence analysis
viruses
Hemagglutinins, Viral
Hemagglutinin Glycoproteins, Influenza Virus
Biology
complex mixtures
chemistry.chemical_compound
Viral Proteins
Consensus sequence
Amino Acid Sequence
Cloning, Molecular
Gene
Peptide sequence
Glycoproteins
Genetics
Multidisciplinary
Base Sequence
Nucleic acid sequence
virus diseases
Antigenic shift
Virology
chemistry
Solubility
Influenza A virus
DNA, Viral
Primer (molecular biology)
DNA
Subjects
Details
- ISSN :
- 00280836
- Volume :
- 287
- Issue :
- 5780
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....470e18c7dacf8f7d21179872b03f1c7c