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Dynamic integration and segregation of amygdala subregional functional circuits linking to physiological arousal
- Source :
- NeuroImage, Vol 238, Iss, Pp 118224-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- The dynamical organization of brain networks is essential to support human cognition and emotion for rapid adaption to ever-changing environment. As the core nodes of emotion-related brain circuitry, the basolateral amygdala (BLA) and centromedial amygdala (CMA) as two major amygdalar nuclei, are recognized to play distinct roles in affective functions and internal states, via their unique connections with cortical and subcortical structures in rodents. However, little is known how the dynamical organization of emotion-related brain circuitry reflects internal autonomic responses in humans. Using resting-state functional magnetic resonance imaging (fMRI) with K-means clustering approach in a total of 79 young healthy individuals (cohort 1: 42; cohort 2: 37), we identified two distinct states of BLA- and CMA-based intrinsic connectivity patterns, with one state (integration) showing generally stronger BLA- and CMA-based intrinsic connectivity with multiple brain networks, while the other (segregation) exhibiting weaker yet dissociable connectivity patterns. In an independent cohort 2 of fMRI data with concurrent recording of skin conductance, we replicated two similar dynamic states and further found higher skin conductance level in the integration than segregation state. Moreover, machine learning-based Elastic-net regression analyses revealed that time-varying BLA and CMA intrinsic connectivity with distinct network configurations yield higher predictive values for spontaneous fluctuations of skin conductance level in the integration than segregation state. Our findings highlight dynamic functional organization of emotion-related amygdala nuclei circuits and networks and its links to spontaneous autonomic arousal in humans.
- Subjects :
- Adult
Male
Cognitive Neuroscience
Rest
Emotions
Neurosciences. Biological psychiatry. Neuropsychiatry
Dynamic states
Biology
Amygdala
050105 experimental psychology
Arousal
Machine Learning
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Connectome
Image Processing, Computer-Assisted
Humans
0501 psychology and cognitive sciences
Emotion
Brain Mapping
medicine.diagnostic_test
Autonomic arousal
Basolateral Nuclear Complex
05 social sciences
Central Amygdaloid Nucleus
fMRI
Cognition
Galvanic Skin Response
Magnetic Resonance Imaging
medicine.anatomical_structure
Neurology
Female
Functional magnetic resonance imaging
Skin conductance
Neuroscience
030217 neurology & neurosurgery
Brain circuitry
Basolateral amygdala
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 10959572
- Volume :
- 238
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....470d9609e3011a7214545a96e2d9d308