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Connectivity characterization of the mouse basolateral amygdalar complex
- Source :
- Nature communications, vol 12, iss 1, Nature Communications, Vol 12, Iss 1, Pp 1-25 (2021), Nature Communications
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions to uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile of BLA projection neurons to inform granular, cell type-specific interrogations is warranted. Here, we apply machine-learning based computational and informatics analysis techniques to the results of circuit-tracing experiments to create a foundational, comprehensive BLA connectivity map. The analyses identify three distinct domains within the anterior BLA (BLAa) that house target-specific projection neurons with distinguishable morphological features. We identify brain-wide targets of projection neurons in the three BLAa domains, as well as in the posterior BLA, ventral BLA, posterior basomedial, and lateral amygdalar nuclei. Inputs to each nucleus also are identified via retrograde tracing. The data suggests that connectionally unique, domain-specific BLAa neurons are associated with distinct behavior networks.<br />The basolateral amygdala is implicated in several behavior-related states including anxiety, autism, and addiction. The authors apply circuit-level pathway tracing methods combined with computational techniques to provide a comprehensive connectivity atlas of the mouse basolateral amygdala complex.
- Subjects :
- 0301 basic medicine
Male
Cell type
Drug Abuse (NIDA Only)
Science
Models, Neurological
General Physics and Astronomy
Action Potentials
Biology
Optogenetics
Inbred C57BL
Neural circuits
Basic Behavioral and Social Science
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
Mice
0302 clinical medicine
Models
mental disorders
Behavioral and Social Science
medicine
Biological neural network
Animals
Projection (set theory)
Neurons
Multidisciplinary
Computational neuroscience
Basolateral Nuclear Complex
Neurosciences
Substance Abuse
General Chemistry
Fear
Retrograde tracing
Brain Disorders
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
nervous system
Neurological
Female
Nerve Net
Nucleus
Neuroscience
030217 neurology & neurosurgery
Algorithms
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nature communications, vol 12, iss 1, Nature Communications, Vol 12, Iss 1, Pp 1-25 (2021), Nature Communications
- Accession number :
- edsair.doi.dedup.....470686adca19b453d4ff9af4a035e557