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Clinical significance of Epstein-Barr virus polymerase chain reaction in cerebrospinal fluid
- Source :
- Encephalitis, Vol 2, Iss 1, Pp 1-8 (2022)
- Publication Year :
- 2022
- Publisher :
- Korean Encephalitis and Neuroinflammation Society, 2022.
-
Abstract
- Purpose: Epstein-Barr virus (EBV) is implicated in various neurological conditions. However, the relationship between EBV DNA in cerebrospinal fluid (CSF) and central nervous system (CNS) infection is unclear. We evaluated the clinical manifestation of patients with EBV DNA detected in CSF.Methods: We reviewed the medical records of patients admitted to Seoul National University Hospital from January 2000 to March 2021 who underwent EBV polymerase chain reaction (PCR) tests in CSF. The subjects were divided into positive and negative groups depending on the presence of EBV DNA, and further clinical information was obtained from positive patients.Results: CSF EBV PCR tests were performed in 807 patients, and 57 (7.1%) tested positive. Pleocytosis was common (81%) in CSF samples with EBV DNA detected, and the proportion was significantly higher than that in samples that were EBV PCR negative (44.5%, p < 0.0001). Among 57 patients with EBV DNA detected in CSF, 51 (89.5%) were diagnosed with CNS infection or inflammatory disorders. Of the 51 patients, 31 (60.8%) had possible etiologies other than EBV. Follow-up evaluation was conducted in 19 of 20 patients, and 63.2% showed a favorable outcome.Conclusion: Positive EBV PCR in CSF is mostly nonspecific and should be interpreted with caution. A comprehensive workup is needed to identify other etiologies before considering EBV as the sole culprit.
- Subjects :
- business.industry
central nervous system infections
Infectious and parasitic diseases
RC109-216
medicine.disease_cause
Epstein–Barr virus
Virology
cerebrospinal fluid
law.invention
Cerebrospinal fluid
law
hemic and lymphatic diseases
Medicine
Clinical significance
Neurology. Diseases of the nervous system
human herpesvirus 4
business
RC346-429
Polymerase chain reaction
epstein-barr virus infections
Subjects
Details
- Language :
- English
- ISSN :
- 27341461 and 27654559
- Volume :
- 2
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Encephalitis
- Accession number :
- edsair.doi.dedup.....46fff4e4f12a308d8fb285ae6c4346cb