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Brain Region and Gene Specificity of Neuropeptide Gene Expression in Cultured Astrocytes
- Source :
- Science. 245:415-417
- Publication Year :
- 1989
- Publisher :
- American Association for the Advancement of Science (AAAS), 1989.
-
Abstract
- Astrocytes have many neuronal characteristics, such as neurotransmitter receptors, ion channels, and neurotransmitter uptake systems. Cultured astrocytes were shown to express certain neuropeptide genes, with specificity for both the gene expressed and the brain region from which the cells were prepared. Somatostatin messenger RNA and peptides were detected only in cerebellar astrocytes, whereas proenkephalin messenger RNA and enkephalin peptides were present in astrocytes of cortex, cerebellum, and striatum. Cholecystokinin was not expressed in any of the cells. These results support the hypothesis that peptides synthesized in astrocytes may play a role in the development of the central nervous system.
- Subjects :
- medicine.medical_specialty
Neurotransmitter uptake
Enkephalin
Enkephalin, Methionine
Radioimmunoassay
Neuropeptide
Biology
Neurotransmitter receptor
Cerebellum
Internal medicine
Gene expression
medicine
Animals
RNA, Messenger
Protein Precursors
Cells, Cultured
Cerebral Cortex
Multidisciplinary
Neuropeptide Gene
Neuropeptides
Enkephalins
Blotting, Northern
Corpus Striatum
Rats
Proenkephalin
Cell biology
Endocrinology
medicine.anatomical_structure
Animals, Newborn
Gene Expression Regulation
nervous system
Astrocytes
Somatostatin
Astrocyte
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 245
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....46ffafb9c2942b8ea436b53e9e1047a0