Back to Search
Start Over
Synovial biopsies in clinical practice and research: current developments and perspectives
- Source :
- Clinical Rheumatology
- Publication Year :
- 2021
- Publisher :
- Springer, 2021.
-
Abstract
- Synovial biopsy techniques have developed and widely expanded over the past few years, in particular due to the development of ultrasound-guided procedures. This article reviews the different techniques, clinical applications, and the latest advances in translational research as well as current challenges and perspectives. The first part focuses on different techniques available for biopsy, along with their feasibility, success rate, tolerance, and training requirements. In the second part, clinical applications are described. Data on diagnostic performances are reported, especially regarding septic arthritis. Translational research applications are described and explained in the final part, from the early histological studies and the first description of pathotype to more recent technologies involving -omics. Latest developments involving single-cell RNA sequence analysis have allowed the discovery of new cell subpopulations with remarkable roles in RA pathophysiology. These studies pave the ground for the discovery of new therapeutic targets and the implementation of personalized therapy in RA. Key Point•This review provides an overview of synovial biopsy techinques and applications especially in clinical and translational research.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Biopsy
Translational research
Review Article
03 medical and health sciences
0302 clinical medicine
Rheumatology
Synovitis
Synovium
Ultrasound
medicine
Humans
Medical physics
Personalized therapy
Ultrasonography
030203 arthritis & rheumatology
Arthritis, Infectious
Synovial biopsy
business.industry
Arthritis
Synovial Membrane
Cell subpopulations
General Medicine
medicine.disease
Clinical Practice
030104 developmental biology
RNA Sequence
business
Subjects
Details
- Language :
- English
- ISSN :
- 07703198
- Database :
- OpenAIRE
- Journal :
- Clinical Rheumatology
- Accession number :
- edsair.doi.dedup.....46fc51a4b90b01f703001ba51a4537a3