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Impact of parental obesity on neonatal markers of inflammation and immune response
- Source :
- International journal of obesity (2005)
- Publication Year :
- 2016
-
Abstract
- Background/Objectives Maternal obesity may influence neonatal and childhood morbidities through increased inflammation and/or altered immune response. Less is known about paternal obesity. We hypothesized that excessive parental weight contributes to elevated inflammation and altered immunoglobulin (Ig) profiles in neonates. Subjects/Methods In the Upstate KIDS Study maternal pre-pregnancy body mass index (BMI) was obtained from vital records and paternal BMI from maternal report. Biomarkers were measured from newborn dried blood spots (DBS) among neonates whose parents provided consent. Inflammatory scores were calculated by assigning one point for each of 5 pro-inflammatory biomarkers above the median and one point for an anti-inflammatory cytokine below the median. Linear regression models and generalized estimating equations were used to estimate mean differences (β) and 95% confidence intervals (CI) in the inflammatory score and Ig levels by parental overweight/obesity status compared to normal weight. Results Among 2974 pregnancies, 51% were complicated by excessive maternal weight (BMI>25), 73% by excessive paternal weight, and 28% by excessive gestational weight gain. Maternal BMI categories of overweight (BMI 25.0-29.9) and obese class II/III (BMI≥35) were associated with increased neonatal inflammation scores (β=0.12, 95% CI: 0.02, 0.21; p=0.02, and β=0.13, CI: −0.002, 0.26; p=0.05, respectively) but no increase was observed in the obese class I group (BMI 30-34.9). Mothers with class I and class II/III obesity had newborns with increased IgM levels (β=0.11, CI: 0.04, 0.17; p=0.001 and β=0.12, CI: 0.05, 0.19); p
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Offspring
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Mothers
030209 endocrinology & metabolism
Overweight
Adaptive Immunity
Article
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Pregnancy
Internal medicine
medicine
Humans
Obesity
Infant Nutritional Physiological Phenomena
Life Style
Inflammation
Nutrition and Dietetics
Parental obesity
biology
business.industry
Interleukin-6
C-reactive protein
Immunity
Infant, Newborn
Maternal Nutritional Physiological Phenomena
medicine.disease
United States
Pregnancy Complications
030104 developmental biology
Endocrinology
C-Reactive Protein
Immunoglobulin M
biology.protein
Female
medicine.symptom
Centers for Disease Control and Prevention, U.S
business
Weight gain
Body mass index
Biomarkers
Subjects
Details
- ISSN :
- 14765497
- Volume :
- 41
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of obesity (2005)
- Accession number :
- edsair.doi.dedup.....46f8bc5d4cf4fba8ba97a906fb568522