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Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins
- Source :
- Genomics. 84:737-744
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Ficolin is a collagenous lectin which plays a crucial role in innate immunity. Three and two ficolins have been identified in human and mice, respectively. To identify the mouse homologue of human H-ficolin and to elucidate the orthology between mouse ficolins A/B and human L-/M-ficolins, the gene structures were explored. The mouse homologue of the H-ficolin gene was identified as a pseudogene on chromosome 4. The mouse ficolin A gene was located far from the ficolin B gene on chromosome 2, whereas the human L-ficolin and M-ficolin genes were close in the region homologous to the ficolin B locus. Together with the exon-intron structures and the phylogenetic tree, these results suggest that ficolin B is the mouse orthologue of M-ficolin and that the genes encoding serum-type ficolins, ficolin A and L-ficolin, were generated independently from the ficolin B/M-ficolin lineage each in mice and primates.
- Subjects :
- Lineage (genetic)
Pseudogene
Molecular Sequence Data
Biology
Polymerase Chain Reaction
Chromosomes
Mice
Phylogenetics
Lectins
Genetics
Animals
Humans
Amino Acid Sequence
Cloning, Molecular
Gene
Phylogeny
Mice, Inbred ICR
Sequence Homology, Amino Acid
Chromosome
Exons
Introns
Mice, Inbred C57BL
Chromosome 4
Lectin pathway
Ficolin
Pseudogenes
Subjects
Details
- ISSN :
- 08887543
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Genomics
- Accession number :
- edsair.doi.dedup.....46f8ae2d194d0639deb0694e35d73f6b