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Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma
- Source :
- Gut. 54(3)
- Publication Year :
- 2005
-
Abstract
- Background and aims: Recent studies have suggested that bacterial coinfection with Helicobacter species in patients already infected with hepatitis C virus (HCV) could be involved in the development of cirrhosis and hepatocellular carcinoma (HCC). A retrospective cross sectional study was performed in order to explore the association between Helicobacter species and HCV associated liver diseases. Methods: The presence of Helicobacter species was tested by polymerase chain reaction on liver samples from four groups of patients. Results: Helicobacter 16S rDNA was found in only 4.2% of liver samples from control patients (n = 24) and in 3.5% of liver samples from patients with non-cirrhotic chronic hepatitis C (n = 29) while it was found in 68.0% of liver samples from patients with HCV positive cirrhosis without HCC (n = 25) as well as in 61.3% of cirrhotic liver samples from patients with HCV positive cirrhosis and HCC (n = 31). In addition, when the HCC tumour tissue was tested (n = 21), 90.5% of samples were positive. DNA from Helicobacter pylori - and Helicobacter pullorum -like organisms was found. Conclusions: There is an association between the presence of Helicobacter species DNA in the liver and hepatitis C cirrhosis, with or without HCC. Indeed, the presence of these bacteria could be the result of structural changes in the liver. Alternatively, Helicobacter species could be a co-risk factor in HCV chronic liver diseases. This result warrants prospective studies to determine the possible causal role of these bacteria in the progression of chronic hepatitis C.
- Subjects :
- Adult
DNA, Bacterial
Liver Cirrhosis
Male
Cirrhosis
Carcinoma, Hepatocellular
Helicobacter pullorum
Hepatitis C virus
Hepacivirus
medicine.disease_cause
Polymerase Chain Reaction
Severity of Illness Index
Helicobacter Infections
Helicobacter
RNA, Ribosomal, 16S
medicine
Humans
Escherichia coli Infections
Retrospective Studies
biology
Helicobacter pylori
Liver Neoplasms
Gastroenterology
Hepatitis C
Hepatitis C, Chronic
Middle Aged
medicine.disease
biology.organism_classification
digestive system diseases
Bacterial Typing Techniques
Cross-Sectional Studies
Liver
Hepatocellular carcinoma
Immunology
Coinfection
Female
Subjects
Details
- ISSN :
- 00175749
- Volume :
- 54
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Gut
- Accession number :
- edsair.doi.dedup.....46e9589802df4080bcaaf33880f87927