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Combination of urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate for the treatment of inflammatory lung diseases: An in vitro study
- Source :
- European Journal of Pharmaceutical Sciences. 120:96-106
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- This in vitro study evaluated, for the first time, the safety and the biological activity of a novel urea-crosslinked hyaluronic acid component and sodium ascorbyl phosphate (HA-CL - SAP), singularly and/or in combination, intended for the treatment of inflammatory lung diseases. The aim was to understand if the combination HA-CL - SAP had an enhanced activity with respect to the combination native hyaluronic acid (HA) - SAP and the single SAP, HA and HA-CL components. Sample solutions displayed pH, osmolality and viscosity values suitable for lung delivery and showed to be not toxic on epithelial Calu-3 cells at the concentrations used in this study. The HA-CL - SAP displayed the most significant reduction in interleukin-6 (IL-6) and reactive oxygen species (ROS) levels, due to the combined action of HA-CL and SAP. Moreover, this combination showed improved cellular healing (wound closure) with respect to HA - SAP, SAP and HA, although at a lower rate than HA-CL alone. These preliminary results showed that the combination HA-CL - SAP could be suitable to reduce inflammation and oxidative stress in lung disorders like acute respiratory distress syndrome, asthma, emphysema and chronic obstructive pulmonary disease, where inflammation is prominent.
- Subjects :
- 0301 basic medicine
Antioxidant
genetic structures
medicine.medical_treatment
Anti-Inflammatory Agents
Pharmaceutical Science
Ascorbic Acid
Pharmacology
medicine.disease_cause
Antioxidants
Sodium ascorbyl phosphate
chemistry.chemical_compound
0302 clinical medicine
Hyaluronic acid
Electric Impedance
Urea
Lung
chemistry.chemical_classification
Viscosity
Chemistry
Biological activity
Hydrogen-Ion Concentration
Drug Combinations
Cross-Linking Reagents
Urea-crosslinked hyaluronic acid
medicine.anatomical_structure
medicine.symptom
Cell Survival
medicine.drug_class
Drug Compounding
Wound healing
Inflammation
Anti-inflammatory
NO
03 medical and health sciences
Cell Line, Tumor
medicine
Humans
Technology, Pharmaceutical
Lung Diseases, Obstructive
Reactive oxygen species
Dose-Response Relationship, Drug
Interleukin-6
Osmolar Concentration
Epithelial Cells
030104 developmental biology
030228 respiratory system
Reactive Oxygen Species
Oxidative stress
Subjects
Details
- ISSN :
- 09280987
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....46e020d7814d4807fea8e91c15665b60