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Intraamniotic Inflammation in Women with Preterm Prelabor Rupture of Membranes
- Source :
- PLoS ONE, Vol 10, Iss 7, p e0133929 (2015), PLoS ONE
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- Objective To characterize subgroups of preterm prelabor rupture of membranes (PPROM) and short-term neonatal outcomes based on the presence and absence of intraamniotic inflammation (IAI) and/or microbial invasion of the amniotic cavity (MIAC). Methods One hundred and sixty-six Caucasian women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis (n=166) and were assayed for interleukin-6 levels by a lateral flow immunoassay. The presence of Ureaplasma species, Mycoplasma hominis, Chlamydia trachomatis, and 16S rRNA was evaluated in the amniotic fluid. IAI was defined as amniotic fluid IL-6 values, measured by a point of care test, higher than 745 pg/mL. Results Microbial-associated IAI (IAI with MIAC) and sterile intraamniotic inflammation (IAI alone) were found in 21% and 4%, respectively, of women with PPROM. Women with microbial-associated IAI had higher microbial loads of Ureaplasma species in the amniotic fluid than women with MIAC alone. No differences in the short-term neonatal morbidity with respect to the presence of microbial-associated IAI, sterile IAI and MIAC alone were found after adjusting for the gestational age at delivery in women with PPROM. Conclusions Microbial-associated but not sterile intraamniotic inflammation is common in Caucasian women with PPROM. The gestational age at delivery but not the presence of inflammation affects the short-term neonatal morbidity of newborns from PPROM pregnancies.
- Subjects :
- Adult
medicine.medical_specialty
Fetal Membranes, Premature Rupture
Amniotic fluid
Preterm labor
lcsh:Medicine
Inflammation
Chorioamnionitis
fluids and secretions
Pregnancy
RNA, Ribosomal, 16S
medicine
Prevalence
Rupture of membranes
Humans
lcsh:Science
Multidisciplinary
Obstetrics
business.industry
Interleukin-6
lcsh:R
Infant, Newborn
medicine.disease
Amniotic Fluid
female genital diseases and pregnancy complications
Neonatal outcomes
embryonic structures
Female
lcsh:Q
medicine.symptom
business
Amniotic cavity
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....46d6ececd2dbdf25fb42df6b24c7580d