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DEGRO practical guidelines for the radiotherapy of non-malignant disorders – Part IV
- Source :
- Strahlentherapie und Onkologie. 191:295-302
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- To summarize the updated DEGRO consensus S2e guideline recommendations for the treatment of benign symptomatic functional disorders with low-dose radiotherapy.This overview reports on the role of low-dose radiotherapy in the treatment of functional disorders in cases of heterotopic ossification (HO) and Graves orbitopathy (GO). The most relevant aspects of the DEGRO S2e Consensus Guideline "Radiation Therapy of Benign Diseases 2014" regarding diagnostics, treatment decision, dose prescription, as well as performance of radiotherapy and results are summarized.For both indications (HO, GO), retrospective and some prospective analyses have shown remarkable effects in terms of symptom relief. Nevertheless, the level of evidence (LoE) and the grade of recommendation (GR) vary: LoE 1-2 and GR A-B (HO), LoE 2 and GR B (GO).Low-dose radiotherapy for benign symptomatic functional disorders has proven to be effective, according to different authors, for 25-100 % of the patients studied and therefore it may be a reasonable prophylactic and therapeutic option if noninvasive or invasive methods have been used without persistent success. For HO, a single-fraction dose of 7-8 Gy or fractionated radiation with five fractions of 3.5 Gy is recommended. For GO, single-fraction doses of 0.3-2.0 Gy, and total doses of 2.4-20 Gy/series, applied in one daily fraction are recommended.
- Subjects :
- medicine.medical_specialty
Evidence-Based Medicine
Radiotherapy
business.industry
Ossification, Heterotopic
medicine.medical_treatment
Non malignant
Guideline
medicine.disease
Surgery
Graves Ophthalmopathy
Radiation therapy
Oncology
Germany
Practice Guidelines as Topic
medicine
Humans
Radiology, Nuclear Medicine and imaging
Heterotopic ossification
Dose Fractionation, Radiation
Radiology
Nuclear Medicine
Low dose radiotherapy
business
Subjects
Details
- ISSN :
- 1439099X and 01797158
- Volume :
- 191
- Database :
- OpenAIRE
- Journal :
- Strahlentherapie und Onkologie
- Accession number :
- edsair.doi.dedup.....46d574421345dbd3a3687e7be240b084