A decade of anti-IL-1 therapy in CAPS - a spectrum of efficacy in this spectrum of diseases

Discovery of the role of the IL-1 inflammasome in CAPS has revolutionised treatment, and anti-IL-1 therapies have successfully switched off disease activity in many patients. More than 110 CAPS patients (including 24 children) in the UK have been treated with drugs targeting IL-1, over 90% of these have had complete resolution of disease.