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Genomic and epidemiological monitoring of yellow fever virus transmission potential
- Source :
- Science, Science, 2018, 361 (6405), pp.894-899. ⟨10.1126/science.aat7115⟩, Science, American Association for the Advancement of Science, 2018, 361 (6405), pp.894-899. ⟨10.1126/science.aat7115⟩, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Science (New York, N.Y.), vol 361, iss 6405, Science, 361 (6405
- Publication Year :
- 2018
- Publisher :
- American Association for the Advancement of Science, 2018.
-
Abstract
- The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.<br />info:eu-repo/semantics/published
- Subjects :
- 0301 basic medicine
Virus transmission
Spatial expansion
[SDV]Life Sciences [q-bio]
Polymerase Chain Reaction
law.invention
Disease Outbreaks
0302 clinical medicine
law
Aedes
2.2 Factors relating to the physical environment
Aetiology
Phylogeny
Multidisciplinary
Yellow fever
Age Factors
Genomics
Sciences bio-médicales et agricoles
3. Good health
Transmission (mechanics)
Infectious Diseases
Epidemiological Monitoring
Yellow fever virus
Early phase
Infection
Brazil
Risk
Evolution
General Science & Technology
030231 tropical medicine
Biology
Age and sex
Vaccine Related
Evolution, Molecular
03 medical and health sciences
Rare Diseases
Sex Factors
Spatio-Temporal Analysis
Biodefense
Yellow Fever
medicine
Genetics
Animals
Humans
Prevention
Molecular
biology.organism_classification
medicine.disease
Virology
030104 developmental biology
Emerging Infectious Diseases
BRASIL
Subjects
Details
- Language :
- English
- ISSN :
- 00368075 and 10959203
- Database :
- OpenAIRE
- Journal :
- Science, Science, 2018, 361 (6405), pp.894-899. ⟨10.1126/science.aat7115⟩, Science, American Association for the Advancement of Science, 2018, 361 (6405), pp.894-899. ⟨10.1126/science.aat7115⟩, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Science (New York, N.Y.), vol 361, iss 6405, Science, 361 (6405
- Accession number :
- edsair.doi.dedup.....46c92ba1efe4bb31ed3efd110e0e31a4