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Mutation screening and association study of the candidate prostate cancer susceptibility genesMSR1,PTEN, andKLF6
- Source :
- The Prostate. 66:1052-1060
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- BACKGROUND MSR1, PTEN, and KLF6 have been implicated as candidate susceptibility genes for prostate tumorigenesis. METHODS Three hundred Jewish prostate cancer patients were screened for alterations in these genes. RESULTS MSR1 was conserved in all patients. PTEN screening revealed a novel missense mutation and a silent change. Five KLF6 alterations were detected in 17 patients, including Q160X, the only nonsense KLF6 germline mutation described to date in a cancer patient. The KLF6 IVS1-27G>A polymorphism, recently associated with prostate cancer risk, was detected in 11.9% of the patients and 17.3% of the controls (P = 0.043). IVS1-27A allele frequency was significantly lower in prostate cancer patients (P = 0.030), specifically in Ashkenazi patients (P = 0.047) compared to controls. CONCLUSIONS We found no evidence that MSR1 and PTEN germline mutations are associated with prostate cancer risk in Jews. The negative association between KLF6 IVS1-27A and prostate cancer risk supports a population-specific effect of susceptibility alleles in prostate tumorigenesis. Prostate 66: 1052–1060, 2006. © 2006 Wiley-Liss, Inc.
- Subjects :
- Adult
Male
Candidate gene
Genotype
Urology
Kruppel-Like Transcription Factors
Mutation, Missense
Biology
medicine.disease_cause
Prostate cancer
Germline mutation
Gene Frequency
Risk Factors
Prostate
Proto-Oncogene Proteins
Kruppel-Like Factor 6
medicine
Humans
Missense mutation
PTEN
Genetic Predisposition to Disease
Genetic Testing
Israel
Germ-Line Mutation
Polymorphism, Genetic
Reverse Transcriptase Polymerase Chain Reaction
PTEN Phosphohydrolase
Prostatic Neoplasms
Scavenger Receptors, Class A
Cancer
DNA, Neoplasm
Middle Aged
medicine.disease
Pedigree
Gene Expression Regulation, Neoplastic
medicine.anatomical_structure
Oncology
biology.protein
Cancer research
Female
Carcinogenesis
Subjects
Details
- ISSN :
- 10970045 and 02704137
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- The Prostate
- Accession number :
- edsair.doi.dedup.....46c8beeef3852f97b53711c7e5d138c3