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The role of Fas-FasL-FADD signaling pathway in arsenic-mediated neuronal apoptosis in vivo and in vitro
- Source :
- Toxicology Letters. 356:143-150
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- The molecular mechanisms underlying arsenic-induced neurotoxicity have not been completely elucidated. Our study aimed to determine the role of the Fas-FasL-FADD signaling pathway in arsenic-mediated neuronal apoptosis. Pathological and molecular biological tests were performed on the cerebral cortex of arsenic-exposed rats and SH-SY5Y neuroblastoma cells. Arsenic induced apoptosis in the cortical neurons, which corresponded to abnormal ultrastructural changes. Mechanistically, arsenic activated the Fas-FasL-FADD signaling pathway and the downstream caspases both in vivo and in vitro. ZB4 treatment reversed the apoptotic effects of arsenic on the SHSY5Y cells. Taken together, arsenic induces neurotoxicity by activating the Fas-FasL-FADD signaling pathway.
- Subjects :
- Male
Neurons
Caspase 8
Fas Ligand Protein
Dose-Response Relationship, Drug
Caspase 3
Fas-Associated Death Domain Protein
General Medicine
Toxicology
Arsenic
Rats
Up-Regulation
Rats, Sprague-Dawley
Random Allocation
Gene Expression Regulation
Cell Line, Tumor
Animals
Humans
Environmental Pollutants
RNA, Messenger
fas Receptor
Signal Transduction
Subjects
Details
- ISSN :
- 03784274
- Volume :
- 356
- Database :
- OpenAIRE
- Journal :
- Toxicology Letters
- Accession number :
- edsair.doi.dedup.....46c6ac27cd9d0022281de7d633032646