Back to Search
Start Over
Daily fluctuations of progesterone and testosterone are associated with fibromyalgia pain severity
- Publication Year :
- 2018
-
Abstract
- The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives. Cortisol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum. A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity. In the entire sample, day to day changes in progesterone (P = .002) as well as testosterone (P = .015) were significantly and inversely correlated with pain severity. There was no relationship between estradiol and pain (P = .551) or cortisol and pain (P = .633). These results suggest that progesterone and testosterone play a protective role in fibromyalgia pain severity. Sex and other hormones may serve to increase as well as decrease fibromyalgia pain severity. Perspective Sex hormones fluctuate normally in women with fibromyalgia, but may still contribute to pain severity.
- Subjects :
- 0301 basic medicine
Adult
Male
Fibromyalgia
Adolescent
Physiology
Pain
macromolecular substances
Severity of Illness Index
E-NDAS
Article
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Humans
Testosterone
Longitudinal Studies
Progesterone
Aged
Likelihood Functions
business.industry
Testosterone (patch)
Venous blood
Middle Aged
medicine.disease
030104 developmental biology
Anesthesiology and Pain Medicine
Neurology
Pain severity
Linear Models
Longitudinal
RC0321
Female
Neurology (clinical)
Day to day
business
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
030217 neurology & neurosurgery
Hormone
Blood sampling
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....46bd9aed7be65590b61127decaccc962