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A miniaturized multi-clamp CMOS amplifier for intracellular neural recording
- Source :
- Nature electronics
- Publication Year :
- 2019
-
Abstract
- Intracellular electrophysiology is a foundational method in neuroscience and uses electrolyte-filled glass electrodes and benchtop amplifiers to measure and control transmembrane voltages and currents. Commercial amplifiers perform such recordings with high signal-to-noise ratios (SNRs) but are often expensive, bulky, and not easily scalable to many channels due to reliance on board-level integration of discrete components. Here, we present a monolithic complementary-metal-oxide-semiconductor (CMOS) multi-clamp amplifier integrated circuit capable of recording both voltages and currents with performance exceeding that of commercial benchtop instrumentation. Miniaturization enables high-bandwidth current mirroring, facilitating the synthesis of large-valued active resistors with lower noise than their passive equivalents. This enables the realization of compensation modules that can account for a wide range of electrode impedances. We validate the amplifier's operation electrically, in primary neuronal cultures, and in acute slices, using both high-impedance sharp and patch electrodes. This work provides a solution for low-cost, high-performance and scalable multi-clamp amplifiers.
- Subjects :
- Computer science
02 engineering and technology
Integrated circuit
Noise (electronics)
Article
law.invention
03 medical and health sciences
law
Hardware_GENERAL
0202 electrical engineering, electronic engineering, information engineering
Miniaturization
Hardware_INTEGRATEDCIRCUITS
Electrical and Electronic Engineering
Instrumentation
Electrical impedance
030304 developmental biology
0303 health sciences
business.industry
Amplifier
020208 electrical & electronic engineering
Electrical engineering
Electronic, Optical and Magnetic Materials
CMOS
visual_art
Electronic component
visual_art.visual_art_medium
Resistor
business
Subjects
Details
- ISSN :
- 25201131
- Volume :
- 2
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Nature electronics
- Accession number :
- edsair.doi.dedup.....46b1c202a071d376678d29687f3d7497