Assessing the Role of Teleoperated Robotic Systems in Biomanipulations - A Case Study on Blastocyst Microinjection

Blastocyst microinjections, like many other biomanipulation tasks, involve delicate and precise manual control of micropipettes under a microscope. The operations are carried out by highly trained operators who spend hours peering through the binoculars of microscopes. As a result, the skills of the operator and the taxing working conditions have a significant impact on the results of biomanipulations. This has led to the development of robotic systems to automate the operations, which have been shown to significantly improve their consistency and efficiency. However, the flexibility of direct operator control is often desired, especially in research environments developing or testing new protocols. In such cases, robotics can still play a significant role to improve biomanipulations when used in connection with an intuitive teleoperation interface. This is shown here for the case of blastocyst microinjection, for which we have developed a new teleoperation system offering improved ergonomics and easy and precise control over the biomanipulation equipment. Here, the performance of expert and naive operators with this system is assessed and compared with results from traditional manual microinjections conducted by experts. The results show that the robotic system allows even naive operators to outperform experts and achieve very high success rates (greater than 80%). Furthermore, the quality of the microinjections tends to improve with the teleoperated robotic system, as birth rate data demonstrates. These results offer evidence that robotics and teleoperation have the potential to significantly improve biomanipulation efficiency while maintaining the flexibility of the operations and eliminating the need for extensive training of microinjection personnel.