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Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches
- Source :
- Nature neuroscience.
- Publication Year :
- 2002
-
Abstract
- Despite high enthusiasm, early attempts to develop clinical treatments based on animal research with neurotrophins were not successful. Here we survey clinical trials with neurotrophins, compared with neurotrophic factors of other gene families, and delineate the most likely reasons for their failure. We then suggest improved methods for regulated local supply of NTs to specific populations of neurons and discuss future therapeutic procedures evolving from the more detailed knowledge of the signal transduction pathways activated by neurotrophins via their receptors.
- Subjects :
- Clinical Trials as Topic
biology
Drug Industry
business.industry
General Neuroscience
Peripheral Nervous System Diseases
Treatment failure
Clinical trial
nervous system
Neurotrophic factors
Central Nervous System Diseases
Drug Design
biology.protein
Medicine
Animals
Drug Evaluation
Humans
Nerve Growth Factors
Treatment Failure
Signal transduction
business
Neuroscience
Neurotrophin
Subjects
Details
- ISSN :
- 10976256
- Database :
- OpenAIRE
- Journal :
- Nature neuroscience
- Accession number :
- edsair.doi.dedup.....46a0cdbe25714bfb09b4fbeeee322214