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Measuring the Symptoms of Pediatric Constipation and Irritable Bowel Syndrome with Constipation: Expert Commentary and Literature Review
- Source :
- The Patient - Patient-Centered Outcomes Research. 7:343-364
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Symptom measurement in pediatric chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) trials requires appropriately developed clinical outcome assessments (COAs).Literature was reviewed to identify symptom COAs meeting regulatory standards. Searches were conducted in Pubmed/Medline, EMBASE, and PsychINFO. Title/abstracts were reviewed to identify qualitative studies and those using COAs to measure pediatric CIC/IBS symptoms. Pediatric functional gastrointestinal experts provided input on relevant symptom-concepts to measure.Review of 1,105 abstracts identified 1 relevant qualitative article and 113 articles including COAs. Symptoms most frequently measured in CIC studies were frequency of bowel movements, fecal incontinence/encopresis, abdominal pain, stool consistency, and painful defecation. Symptoms most frequently measured in IBS were abdominal pain, abdominal distention/bloating, stool consistency, frequency of bowel movements, and gas. Evidence of development/validity of COAs was limited. Expert feedback was broadly consistent with the literature.Findings demonstrate consistency in the literature on key CIC/IBS symptoms to measure in pediatric trials, but existing COAs do not meet regulatory standards.
- Subjects :
- medicine.medical_specialty
Abdominal pain
Pediatrics
Constipation
Adolescent
Outcome assessment
Severity of Illness Index
Irritable Bowel Syndrome
Chronic idiopathic constipation
Outcome Assessment, Health Care
Severity of illness
medicine
Humans
Child
Symptom measurement
Irritable bowel syndrome
business.industry
Infant
medicine.disease
Abdominal Pain
Treatment Outcome
Child, Preschool
Chronic Disease
Physical therapy
Defecation
medicine.symptom
business
Subjects
Details
- ISSN :
- 11781661 and 11781653
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- The Patient - Patient-Centered Outcomes Research
- Accession number :
- edsair.doi.dedup.....4698380744ae1bc8819e38d38b434f17