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Risk of Immunodeficiency Virus Infection May Increase with Vaccine-Induced Immune Response
- Publication Year :
- 2012
- Publisher :
- American Society for Microbiology, 2012.
-
Abstract
- To explore the efficacy of novel complementary prime-boost immunization regimens in a nonhuman primate model for HIV infection, rhesus monkeys primed by different DNA vaccines were boosted with virus-like particles (VLP) and then challenged by repeated low-dose rectal exposure to simian immunodeficiency virus (SIV). Characteristic of the cellular immune response after the VLP booster immunization were high numbers of SIV-specific, gamma interferon-secreting cells after stimulation with inactivated SIV particles, but not SIV peptides, and the absence of detectable levels of CD8 + T cell responses. Antibodies specific to SIV Gag and SIV Env could be induced in all animals, but, consistent with a poor neutralizing activity at the time of challenge, vaccinated monkeys were not protected from acquisition of infection and did not control viremia. Surprisingly, vaccinees with high numbers of SIV-specific, gamma interferon-secreting cells were infected fastest during the repeated low-dose exposures and the numbers of these immune cells in vaccinated macaques correlated with susceptibility to infection. Thus, in the absence of protective antibodies or cytotoxic T cell responses, vaccine-induced immune responses may increase the susceptibility to acquisition of immunodeficiency virus infection. The results are consistent with the hypothesis that virus-specific T helper cells mediate this detrimental effect and contribute to the inefficacy of past HIV vaccination attempts (e.g., STEP study).
- Subjects :
- Male
Risk
T cell
animal diseases
viruses
Immunology
Simian Acquired Immunodeficiency Syndrome
Gene Products, gag
CD8-Positive T-Lymphocytes
medicine.disease_cause
Microbiology
DNA vaccination
Interferon-gamma
Mice
Immune system
Virology
Vaccines and Antiviral Agents
medicine
Cytotoxic T cell
Animals
Humans
biology
SAIDS Vaccines
virus diseases
Gene Products, env
Simian immunodeficiency virus
Macaca mulatta
Vaccination
medicine.anatomical_structure
HEK293 Cells
Immunization
Insect Science
Immune System
biology.protein
Macaca
Female
Simian Immunodeficiency Virus
Antibody
Peptides
T-Lymphocytes, Cytotoxic
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4692ac4a1fb22b649f62bf8fd5b99334