Pragmatic global dosing recommendations for the 3-month, once-weekly rifapentine and isoniazid preventive TB regimen in children

The End TB Strategy, proposed by the World Health Organization (WHO) in 2014, calls for a 90% reduction in tuberculosis (TB)-related deaths and an 80% reduction in the TB incidence by 2030 [1]. TB remains a leading cause of death in children under five years of age [2], and interventions to eliminate preventable child deaths from TB are urgently needed. Additional and effective TB prevention measures are crucial for the End TB Strategy goals to be met [3]. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Dr. Radtke has nothing to disclose. Conflict of interest: Dr. Hibma reports I am an employee of Pfizer Inc. Conflict of interest: Dr. Hesseling has nothing to disclose. Conflict of interest: Dr. Savic has nothing to disclose.