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In Silico Analysis of P450s and Their Role in Secondary Metabolism in the Bacterial Class Gammaproteobacteria
- Source :
- Molecules, Volume 26, Issue 6, Molecules, Vol 26, Iss 1538, p 1538 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- The impact of lifestyle on shaping the genome content of an organism is a well-known phenomenon and cytochrome P450 enzymes (CYPs/P450s), heme-thiolate proteins that are ubiquitously present in organisms, are no exception. Recent studies focusing on a few bacterial species such as Streptomyces, Mycobacterium, Cyanobacteria and Firmicutes revealed that the impact of lifestyle affected the P450 repertoire in these species. However, this phenomenon needs to be understood in other bacterial species. We therefore performed genome data mining, annotation, phylogenetic analysis of P450s and their role in secondary metabolism in the bacterial class Gammaproteobacteria. Genome-wide data mining for P450s in 1261 Gammaproteobacterial species belonging to 161 genera revealed that only 169 species belonging to 41 genera have P450s. A total of 277 P450s found in 169 species grouped into 84 P450 families and 105 P450 subfamilies, where 38 new P450 families were found. Only 18% of P450s were found to be involved in secondary metabolism in Gammaproteobacterial species, as observed in Firmicutes as well. The pathogenic or commensal lifestyle of Gammaproteobacterial species influences them to such an extent that they have the lowest number of P450s compared to other bacterial species, indicating the impact of lifestyle on shaping the P450 repertoire. This study is the first report on comprehensive analysis of P450s in Gammaproteobacteria.
- Subjects :
- lifestyle
Firmicutes
In silico
Gammaproteobacteria
Pharmaceutical Science
Cyanobacteria
Streptomyces
Genome
digestive system
Article
Analytical Chemistry
Mycobacterium
lcsh:QD241-441
Evolution, Molecular
03 medical and health sciences
lcsh:Organic chemistry
Cytochrome P-450 Enzyme System
Drug Discovery
polycyclic compounds
Computer Simulation
Physical and Theoretical Chemistry
Secondary metabolism
Organism
Phylogeny
030304 developmental biology
Genetics
0303 health sciences
secondary metabolism
Phylogenetic tree
biology
030306 microbiology
Organic Chemistry
Genomics
biology.organism_classification
biosynthetic gene clusters
genome data mining
Chemistry (miscellaneous)
cytochrome P450 monooxygenases
Multigene Family
Molecular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....468cad4396cd9486a4293b6991c7d69a
- Full Text :
- https://doi.org/10.3390/molecules26061538