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Maternal consumption of fish oil programs reduced adiposity in broiler chicks
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group UK, 2017.
-
Abstract
- Maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3) and docosahexaenoic acid (22:6 n-3) has been associated with reduced adiposity in children, suggesting the possibility to program adipose development through dietary fatty acids before birth. This study determined if enriching the maternal diet in fish oil, the primary source of EPA and DHA, affected adipose development in offspring. Broiler chickens were used because they are obesity-prone, and because fatty acids provided to the embryo can be manipulated through the hen diet. Hens were fed diets supplemented (2.8% wt:wt) with corn oil (CO; n-6) or fish oil (FO; n-3) for 28 d. Chicks from both maternal diet groups were fed the same diet after hatch. Maternal FO consumption enriched chick adipose tissue in EPA and DHA and reduced adiposity by promoting more, but smaller, adipocytes. This adipocyte profile was paralleled by lower expression of the adipogenic regulator PPARG and its co-activator PPARGC1B, and elevated expression of LPL. Proteomics identified 95 differentially abundant proteins between FO and CO adipose tissue, including components of glucose metabolism, lipid droplet trafficking, and cytoskeletal organization. These results demonstrate that the maternal dietary fatty acid profile programs offspring adipose development.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Multidisciplinary
Offspring
lcsh:R
Adipose tissue
lcsh:Medicine
Biology
Carbohydrate metabolism
Fish oil
Eicosapentaenoic acid
Article
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
Endocrinology
chemistry
Docosahexaenoic acid
Internal medicine
Adipocyte
medicine
lcsh:Q
lcsh:Science
Corn oil
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....46486eacffe627c355eafc280f61ad61