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Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps
Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The aim of this study was to investigate the feasibility of quantitative assessment of the therapeutic response in psoriatic arthritis (PsA) by measuring iodine uptake using a Dual-energy CT (DECT) iodine map. The study included 74 symptomatic and 74 matching non-symptomatic joints of 26 consecutive PsA patients who underwent two contrast enhanced DECTs of the hand or foot, pre and post medical interventions. Symptomatic and matched non-symptomatic control joints were scored with the PsA DECT Scoring System (PsADECTS), which was derived by modifying the PsA MRI Scoring System (PsAMRIS), a recently validated scoring system that assesses PsA changes on MRI. Quantified iodine uptake measured using the DECT iodine map was compared to the PsADECTS score. Efficacy of PsA treatment was confirmed by the improved clinical findings. Both PsADECTS and iodine uptake also showed significant improvement after treatment (Wilcoxon signed-rank test: z = 7.38, p
- Subjects :
- Adult
Male
Wilcoxon signed-rank test
Radiography
Contrast Media
lcsh:Medicine
Arthritis
chemistry.chemical_element
Iodine
Severity of Illness Index
Article
030218 nuclear medicine & medical imaging
Radiography, Dual-Energy Scanned Projection
Tendons
03 medical and health sciences
Psoriatic arthritis
Absorptiometry, Photon
0302 clinical medicine
Finger Joint
Foot Joints
Severity of illness
Image Processing, Computer-Assisted
medicine
Humans
lcsh:Science
Aged
Retrospective Studies
Aged, 80 and over
030203 arthritis & rheumatology
Multidisciplinary
business.industry
Arthritis, Psoriatic
lcsh:R
Reproducibility of Results
Retrospective cohort study
Middle Aged
medicine.disease
Radiographic Image Enhancement
Treatment Outcome
chemistry
Feasibility Studies
Female
lcsh:Q
business
Nuclear medicine
Quantitative analysis (chemistry)
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....4642b917eee001ec3aa80027e2bcaa25
- Full Text :
- https://doi.org/10.1038/s41598-020-58235-9