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Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps

Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps

Authors :
Takeshi Fukuda
Mami Momose
Tadashi Tokashiki
Yoshinori Umezawa
Reina Kayama
Akihiko Asahina
Kunihiko Fukuda
Sho Ogiwara
Source :
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Scientific Reports
Publication Year :
2020
Publisher :
Springer Science and Business Media LLC, 2020.

Abstract

The aim of this study was to investigate the feasibility of quantitative assessment of the therapeutic response in psoriatic arthritis (PsA) by measuring iodine uptake using a Dual-energy CT (DECT) iodine map. The study included 74 symptomatic and 74 matching non-symptomatic joints of 26 consecutive PsA patients who underwent two contrast enhanced DECTs of the hand or foot, pre and post medical interventions. Symptomatic and matched non-symptomatic control joints were scored with the PsA DECT Scoring System (PsADECTS), which was derived by modifying the PsA MRI Scoring System (PsAMRIS), a recently validated scoring system that assesses PsA changes on MRI. Quantified iodine uptake measured using the DECT iodine map was compared to the PsADECTS score. Efficacy of PsA treatment was confirmed by the improved clinical findings. Both PsADECTS and iodine uptake also showed significant improvement after treatment (Wilcoxon signed-rank test: z = 7.38, p

Details

ISSN :
20452322
Volume :
10
Database :
OpenAIRE
Journal :
Scientific Reports
Accession number :
edsair.doi.dedup.....4642b917eee001ec3aa80027e2bcaa25
Full Text :
https://doi.org/10.1038/s41598-020-58235-9